Document Detail

Nitric oxide regulates renal hemodynamics and urinary sodium excretion in dogs.
MedLine Citation:
PMID:  8175171     Owner:  NLM     Status:  MEDLINE    
The goal of this study was to determine whether nitric oxide has a long-term role in the control of renal hemodynamics and the relation between arterial pressure and urinary sodium excretion. Studies were conducted over a 25-day period in seven conscious dogs equipped with indwelling vascular catheters and an electromagnetic flow probe on the iliac artery. Nitric oxide synthesis was inhibited by continuous intravenous infusion of NG-nitro-L-arginine methyl ester at 37.1 nmol/kg per minute, and the effects of low, normal, and high sodium intakes were determined. Significant nitric oxide synthesis inhibition was evidenced by a decrease in the depressor and flow responses to systemic acetylcholine administration. During the normal sodium intake plus nitro-arginine period, arterial pressure increased to hypertensive levels, averaging 120 +/- 4% of control; renal vascular resistance increased to an average of 134 +/- 8% of control; glomerular filtration rate and renal plasma flow decreased to 83 +/- 3% and 81 +/- 3% of control, respectively; and no changes occurred in filtration fraction, plasma renin activity, plasma concentrations of aldosterone and cortisol, urinary sodium excretion, sodium balance, fractional excretion of sodium, urine volume, and volume balance. Arterial pressure increased further to 130 +/- 3% of control during high salt intake, and sodium balance was achieved at each sodium intake despite the increase in arterial pressure because of a hypertensive shift in the relation between urinary sodium excretion and arterial pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
R D Manning; L Hu
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  23     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-06-07     Completed Date:  1994-06-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  619-25     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.
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MeSH Terms
Aldosterone / blood
Arginine / analogs & derivatives,  pharmacology
Glomerular Filtration Rate / drug effects
Hemodynamics / drug effects
Kidney / physiology*
NG-Nitroarginine Methyl Ester
Nitric Oxide / physiology*
Renin / blood
Sodium / urine*
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 52-39-1/Aldosterone; 74-79-3/Arginine; 7440-23-5/Sodium; EC

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