| Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish. | |
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MedLine Citation:
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PMID: 19822749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The blood and lymphatic vasculatures are structurally and functionally coupled in controlling tissue perfusion, extracellular interstitial fluids, and immune surveillance. Little is known, however, about the molecular mechanisms that underlie the regulation of bloodlymphatic vessel connections and lymphatic perfusion. Here we show in the adult zebrafish and glass catfish (Kryptopterus bicirrhis) that blood-lymphatic conduits directly connect arterial vessels to the lymphatic system. Under hypoxic conditions, arterial-lymphatic conduits (ALCs) became highly dilated and linearized by NO-induced vascular relaxation, which led to blood perfusion into the lymphatic system. NO blockage almost completely abrogated hypoxia-induced ALC relaxation and lymphatic perfusion. These findings uncover mechanisms underlying hypoxia-induced oxygen compensation by perfusion of existing lymphatics in fish. Our results might also imply that the hypoxia-induced NO pathway contributes to development of progression of pathologies, including promotion of lymphatic metastasis by modulating arterial-lymphatic conduits, in the mammalian system. |
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Authors:
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Lasse Dahl Ejby Jensen; Renhai Cao; Eva-Maria Hedlund; Iris Söll; Jon O Lundberg; Giselbert Hauptmann; John Fleng Steffensen; Yihai Cao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-12 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 106 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-28 Completed Date: 2009-11-24 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 18408-13 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Karolinska Institute, SE-171 77 Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Anoxia / metabolism* Arteries / metabolism* Catfishes / metabolism* Lymphatic Vessels / metabolism* Nitric Oxide / metabolism* Perfusion Zebrafish / metabolism* |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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