Document Detail

Nitric oxide pathway in the nucleus raphe magnus modulates hypoxic ventilatory response but not anapyrexia in rats.
MedLine Citation:
PMID:  15261097     Owner:  NLM     Status:  MEDLINE    
Nucleus raphe magnus (NRM) is one of the cellular groups of the brainstem that is involved in the physiologic responses to hypoxia and contains nitric oxide (NO) synthase. In the present study, we assessed the role of NO pathway in the NRM on the hypoxic ventilatory response (HVR) and anapyrexia (a regulated decrease in body temperature). To this end, pulmonary ventilation (VE) and body temperature (Tb) of male Wistar rats were measured before and after microinjection of N-monomethyl-L-arginine (L-NMMA, a nonselective nitric oxide synthase inhibitor, 12.5 microg/0.1 microl) into the NRM, followed by hypoxia. Control rats received microinjection of saline. Under resting conditions, L-NMMA treatment did not affect pulmonary VE or Tb. Typical hypoxia-induced hyperventilation and anapyrexia were observed after saline treatment. L-NMMA into the NRM reduced the HVR but did not affect hypoxia-induced anapyrexia. In conclusion, the present study indicates that NO in the NRM is involved in HVR, exerts an inhibitory modulation on the NRM neurons but does not mediate hypoxia-induced anapyrexia.
Tatiane B Nucci; Luiz G S Branco; Luciane H Gargaglioni
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  1017     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-20     Completed Date:  2004-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Avenida do Cafe s/No. 14040-904, Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil.
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MeSH Terms
Anoxia / physiopathology*
Body Temperature / drug effects
Body Temperature Regulation / drug effects,  physiology*
Enzyme Inhibitors / pharmacology
Microinjections / methods
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / metabolism*
Plethysmography / methods
Pulmonary Ventilation / drug effects
Raphe Nuclei / drug effects,  metabolism*
Rats, Wistar
Respiration* / drug effects
Tidal Volume / drug effects
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester

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