| Nitric oxide and pancreatic islet blood flow after induced portal hypertension in rats. | |
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MedLine Citation:
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PMID: 9094159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Portal hypertension (PH) is associated with a hyperdynamic splanchnic circulation, partially mediated by nitric oxide-dependent mechanisms. The aim of the present study was to evaluate the influence of PH and nitric oxide on pancreatic islet blood flow. PH was induced by a calibrated stenosis of the portal vein in male Sprague-Dawley rats. Control were sham-operated. Ten days later pancreatic, duodenal, colonic, and arterial hepatic blood flows were measured with microspheres. All splanchnic blood flow values were markedly increased in the PH rats. The fraction of whole pancreatic blood flow diverted through the islets increased from approximately 5 to 15%. Intravenous administration of the nitric oxide synthase inhibitor NG-nitro-L-arginine (25 mg/kg body weight) in rats with PH 10 min before blood flow measurements decreased pancreatic, duodenal, colonic, and arterial hepatic blood flow to control values. Pancreatic islet blood flow was also decreased, but more markedly than that of the whole pancreas. Pancreatic islet morphology was normal, and the rate of islet cell replication was not influenced. PH induced a preferential increase in pancreatic islet blood flow, which is likely to be associated with an increased production of nitric oxide. |
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Authors:
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L Jansson; A Andersson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 14 ISSN: 0885-3177 ISO Abbreviation: Pancreas Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-06-20 Completed Date: 1997-06-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 280-4 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Enzyme Inhibitors / pharmacology Hypertension, Portal / etiology, physiopathology* Islets of Langerhans / blood supply*, drug effects Male Nitric Oxide / physiology* Nitric Oxide Synthase / antagonists & inhibitors Nitroarginine / pharmacology Rats Rats, Sprague-Dawley Splanchnic Circulation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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