Document Detail


Nitric oxide and oxygen utilization: exercise, heart failure and diabetes.
MedLine Citation:
PMID:  10421971     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to regulating vascular tone, there is increasing evidence for the involvement of NO in the modulation of oxygen consumption. Our in-vitro studies indicated that exogenous and endogenous NO reduces the consumption of oxygen in isolated canine skeletal and cardiac muscle, which is probably related to its direct effect on mitochondria, i.e. cytochrome oxidase. In resting, conscious dogs, the blockade of NO synthesis results in an increase in total oxygen consumption. During exercise, there is a significant increase in the release of NO from the coronary circulation in conscious dogs, and there are greater increases in total oxygen consumption, and oxygen consumption in skeletal muscle and in the heart when NO synthesis is blocked. Our results suggest that NO plays a role in matching blood flow to tissue metabolism at rest and during exercise. The modulation of the consumption of O2 by endogenous NO in skeletal or cardiac muscle is blunted after the development of heart failure or diabetes. After heart failure, the heart switches from fatty acid to glucose metabolism, suggesting that NO also plays a role in the regulation of metabolism in the heart.
Authors:
G Zhao; R D Bernstein; T H Hintze
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Coronary artery disease     Volume:  10     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-20     Completed Date:  1999-09-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  315-20     Citation Subset:  IM    
Affiliation:
Department of Physiology, New York Medical College, Valhalla 10595, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Experimental / physiopathology*
Dogs
Exercise / physiology*
Heart Failure / physiopathology*
Humans
Nitric Oxide / physiology*
Oxygen Consumption
Grant Support
ID/Acronym/Agency:
HL 50142/HL/NHLBI NIH HHS; HL 53053/HL/NHLBI NIH HHS; HL-PO-1-43023/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide

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