| Nitric oxide: a new concept in chronic sinusitis pathogenesis. | |
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MedLine Citation:
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PMID: 17826536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Exhaled NO is produced mainly in paranasal sinuses and nasal mucosa. Nasal NO has been suggested to have a variety of effects in nasal cavity. Decreased exhaled NO is found in chronic sinusitis, and NO metabolite levels are increased in animal models of chronic sinusitis, suggesting a role for them in sinusitis pathogenesis. There was no data available on human NO metabolite level. MATERIALS AND METHODS: We lavaged maxillary sinuses in a control and 2 patient groups. The control group was patients who underwent functional endoscopic sinus surgery (FESS) due to any other reason than chronic sinusitis. The patient groups had chronic rhinosinusitis with and without polyposis who underwent FESS. Maxillary sinuses were lavaged during FESS, and NO metabolites (nitrate and nitrite) were lavaged in the lavage fluid. RESULTS: Nitric oxide metabolite levels (mean +/- SEM) were 8.085 +/- 1.43 mumol/L in healthy maxillary sinus lavage fluid and 18.04 +/- 3.51 and 16.78 +/- 2.91 mumol/L in chronic rhinosinusitis with and without polyposis, respectively. Lavage fluid of sinuses with chronic sinusitis had elevated levels of NO metabolites, which were significantly higher than the control group. The difference between the chronic sinusitis with and without polyposis groups was not significant. CONCLUSIONS: Nitric oxide metabolites were significantly higher in maxillary sinuses of patients with chronic sinusitis. Elevated levels of NO and NO metabolites in sinusitis might damage healthy sinus epithelium. NO metabolites may have an important role in sinusitis pathogenesis. |
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Authors:
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Mohsen Naraghi; Armin Farajzadeh Deroee; MohammadReza Ebrahimkhani; Samira Kiani; AhmadReza Dehpour |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of otolaryngology Volume: 28 ISSN: 0196-0709 ISO Abbreviation: Am J Otolaryngol Publication Date: 2007 Sep-Oct |
Date Detail:
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Created Date: 2007-09-10 Completed Date: 2008-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000029 Medline TA: Am J Otolaryngol Country: United States |
Other Details:
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Languages: eng Pagination: 334-7 Citation Subset: IM |
Affiliation:
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Iranian Rhinology Research Society, Department of Otorhinolaryngology, Head and Neck surgery & Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran. info@naraghi.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Case-Control Studies Chronic Disease Female Humans Male Mucociliary Clearance Nasal Mucosa / metabolism, physiopathology Nitric Oxide / metabolism* Sinusitis / etiology*, metabolism, physiopathology, surgery |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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