Document Detail

Nitric oxide and muscle blood flow in exercise.
MedLine Citation:
PMID:  18347667     Owner:  NLM     Status:  MEDLINE    
Despite being the subject of investigation for well over 100 years, the nature of exercising muscle blood flow control remains, in many respects, poorly understood. In this review we focus on the potential role of nitric oxide in vasodilation of muscle resistance vessels during a bout of exercise. Its contribution is explored in the context of whether it contributes to steady-state exercise hyperemia, the dynamic adjustment of muscle blood flow to exercise, or the modulation of sympathetic vasoconstriction in exercising muscle. It appears that the obligatory role of nitric oxide in all three of these categories is modest at best. The elucidation of the integrated nature of exercise hyperemia control in terms of synergy and redundancy of mechanism interaction remains in its infancy, and much more remains to be learned about the role of nitric oxide in this type of integrated control.
Michael E Tschakovsky; Michael J Joyner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  33     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-05-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  151-61     Citation Subset:  IM    
School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 3N6.
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MeSH Terms
Blood Vessels / innervation,  physiology
Exercise / physiology*
Muscle, Skeletal / blood supply*,  physiology*
Nitric Oxide / physiology*
Physical Conditioning, Animal / physiology
Regional Blood Flow / physiology*
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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