Document Detail

Nitric oxide and molsidomine in the management of pulmonary hypertension in Takayasu's arteritis.
MedLine Citation:
PMID:  11157624     Owner:  NLM     Status:  MEDLINE    
We present three patients with pulmonary hypertension in Takayasu's arteritis who showed long-term favorable response, clinically and hemodynamically, to nitric oxide donor molsidomine. In these patients, nitric oxide inhalation was effective in reducing pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR). Molsidomine (single dose of 4 mg p.o.) was also effective in reducing PAP and PVR, but nifedipine was not. With molsidomine, 4 mg tid, dyspnea, exercise capacity, and hemodynamic parameters were improved. These favorable responses have lasted during the 3-month follow-up period in all patients.
S D Lee; D S Kim; T S Shim; C M Lim; Y Koh; W S Kim; W D Kim
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  119     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  302-7     Citation Subset:  AIM; IM    
Department of Internal Medicine, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea.
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MeSH Terms
Drug Therapy, Combination
Hypertension, Pulmonary / drug therapy*
Middle Aged
Molsidomine / administration & dosage*
Nitric Oxide Donors / administration & dosage*
Pulmonary Wedge Pressure / drug effects
Takayasu Arteritis / drug therapy*
Treatment Outcome
Vascular Resistance / drug effects
Reg. No./Substance:
0/Nitric Oxide Donors; 25717-80-0/Molsidomine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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