Document Detail

Nitric oxide modulates but does not impair myogenic vasoconstriction of the afferent arteriole in spontaneously hypertensive rats. Studies in the isolated perfused hydronephrotic kidney.
MedLine Citation:
PMID:  7768564     Owner:  NLM     Status:  MEDLINE    
Renal autoregulation curves are reset toward higher renal arterial pressure in spontaneously hypertensive rats (SHR) compared with those in Wistar-Kyoto rats (WKY). We previously demonstrated that myogenic afferent arteriolar constriction is shifted to higher renal arterial pressure. To investigate whether nitric oxide participates in the regulation of myogenic tone, we examined the effect of nitro-L-arginine on myogenic afferent arteriolar constriction in kidneys from SHR and WKY, using the isolated perfused hydronephrotic kidney. Elevating pressures from 40 to 80 mm Hg caused increases in afferent arteriolar diameter in WKY (from 18.2 +/- 0.4 to 19.0 +/- 0.3 micron) and SHR (from 17.3 +/- 0.6 to 18.4 +/- 0.6 micron). Further pressure elevation elicited constriction at 100 mm Hg in WKY (17.9 +/- 0.3 micron), but significant constriction was observed at 120 mm Hg in SHR (17.3 +/- 0.6 micron), indicating a resetting in myogenic responses to higher pressures. In WKY, after treatment with 10 mumol/L nitro-L-arginine, afferent arterioles exhibited pressure-dependent constriction, with a threshold pressure for constriction at 80 mm Hg. The addition of 100 mumol/L nitro-L-arginine had no further effect on myogenic responsiveness in WKY. In contrast, in SHR, nitro-L-arginine dose-dependently shifted the myogenic responses toward lower renal arterial pressure, with threshold pressures for constriction observed at 100 mm Hg (10 mumol/L) and 80 mm Hg (100 mumol/L).(ABSTRACT TRUNCATED AT 250 WORDS)
K Hayashi; H Suzuki; T Saruta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  25     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-06-30     Completed Date:  1995-06-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1212-9     Citation Subset:  IM    
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Arginine / analogs & derivatives,  pharmacology
Arterioles / physiopathology
Hydronephrosis / physiopathology
Hypertension / physiopathology*
Kidney / physiopathology*
Nitric Oxide / physiology*
Nitroprusside / pharmacology
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Vasopressin / drug effects
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Receptors, Vasopressin; 10102-43-9/Nitric Oxide; 15078-28-1/Nitroprusside; 2149-70-4/Nitroarginine; 74-79-3/Arginine

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