| Nitric oxide modulates angiotensin II-induced drinking behavior in the near-term ovine fetus. | |
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MedLine Citation:
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PMID: 10739535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Human and ovine fetuses demonstrate an enhanced rate of spontaneous and angiotensin II-stimulated swallowing. Angiotensin II and nitric oxide synthase have been localized to thirst centers in the brain. This study was performed to determine whether central nitric oxide contributes to the regulation of angiotensin II-induced fetal swallowing. STUDY DESIGN: Six pregnant ewes with near-term singleton fetuses were chronically prepared with fetal vascular and lateral ventricle catheters and electrocorticogram and esophageal electromyogram electrodes. After a 2-hour control period, fetuses were administered serial lateral ventricle injections (1 mL) of angiotensin II (3.2 microg; time, 2 hours) and N omega-nitro-L -arginine methyl ester (3 mg; time, 3 hours) and a repeat angiotensin II injection (3.2 microg; time, 5 hours). All fetuses received an additional control study of lateral ventricle injections of artificial cerebrospinal fluid on a previous day. RESULTS: Angiotensin II injection significantly increased mean +/- SEM fetal swallowing (0.9 +/- 0.1 to 2.7 +/- 0.4 swallows/min). N omega-nitro-L -arginine methyl ester significantly decreased fetal swallowing to below the basal rate (0.4 +/- 0.1 swallows/min), and swallowing did not increase with the second angiotensin II dose (in the presence of nitric oxide blockade). CONCLUSIONS: These results demonstrate that inhibition of central nitric oxide suppresses fetal swallowing behavior in response to central angiotensin II. We speculate that tonic nitric oxide facilitates angiotensin II swallowing stimulation by maintenance of glutamate activation of hypothalamic N -methyl-D -aspartate receptors. |
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Authors:
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M A El-Haddad; C R Chao; S x Ma; M G Ross |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 182 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-05-02 Completed Date: 2000-05-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 713-9 Citation Subset: AIM; IM |
Affiliation:
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Perinatal Research Laboratories, Harbor-University of California, Los Angeles Medical Center, University of California, Los Angeles School of Medicine, Torrance, CA 90502, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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administration & dosage,
pharmacology* Animals Behavior, Animal / drug effects Deglutition / drug effects Drinking Behavior / drug effects Enzyme Inhibitors / pharmacology Female Fetus / drug effects Gestational Age Hemodynamics Injections, Intraventricular NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / physiology* Pregnancy Sheep |
| Grant Support | |
ID/Acronym/Agency:
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HD35947/HD/NICHD NIH HHS; HL40899/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 11128-99-7/Angiotensin II; 50903-99-6/NG-Nitroarginine Methyl Ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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