Document Detail

Nitric oxide metabolites in preterm and induced labor.
MedLine Citation:
PMID:  14576471     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nitric oxide has potent relaxant effects on the pregnant uterus and has been associated with a quiescent uterus in animal and human studies. Nitric oxide donors have been used to arrest preterm labor and a reduction in nitric oxide production has been reported before the onset of labor. OBJECTIVE: The aim of the study was to estimate the serum levels of nitrate and nitrite in women undergoing spontaneous preterm labor and induced labor. MATERIALS AND METHOD: Venous blood was drawn from 39 patients before the onset of labor (control) and also from 17 patients undergoing induction of labor who were in active labor (study group A), and 24 patients in spontaneous preterm labor (study group B). Serum concentrations of nitrate and nitrite were estimated in the samples using the HPLC method. RESULTS: The maternal age of the patients was similar in all the groups. There was no significant difference in the mean gestational age at delivery between the control and group-A patients (38.86 vs. 38.29 weeks); however, there was a significant difference between the control and group-B patients (38.86 vs. 30.92; p < 0.0001), and between study groups A and B (38.29 vs. 30.92 weeks; p < 0.0001). The mean serum levels of nitrite in groups A and B (0.563 +/- 0.15 and 0.512 +/- 0.13, respectively) were significantly lower than the level in the control group (0.915 +/- 0.13; p < 0.0001). Although the serum nitrate levels in study groups A and B were lower than in the control group, this difference was not significant. The maternal outcome was satisfactory but, as expected, the mean birth weight of the babies in group B (1,665.73 +/- 863.84 g) was significantly lower than the birth weights in the control and group-A patients (p < 0.0001). CONCLUSION: There is a drop in nitric oxide production in active preterm labor and induced labor. These findings need to be confirmed in larger studies to establish the role of nitric oxide in the initiation of labor.
Michael F E Diejomaoh; Alexander E Omu; Sami Taher; Nasser Al-Busiri; Tunde Fatinikun; Sanjit Fernandes; Saed Al-Othman
Publication Detail:
Type:  Journal Article     Date:  2003-10-23
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  56     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-10     Completed Date:  2004-04-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Department of Obstetrics and Gynaecology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
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MeSH Terms
Birth Weight
Chromatography, High Pressure Liquid
Gestational Age
Labor, Induced*
Nitrates / blood
Nitric Oxide / metabolism*
Nitrites / blood
Obstetric Labor, Premature / blood*
Pregnancy Outcome
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide

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