Document Detail

Nitric oxide may trigger lactation in humans.
MedLine Citation:
PMID:  9427887     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether nitric oxide is synthesized in the breast and plays a role in lactation. DESIGN: Concentrations of biopterin, neopterin, and the total concentration of nitrite plus nitrate, a marker for nitric oxide generation were measured in 242 samples of breast milk obtained from 39 women during postpartum days 1 to 30. The total concentration of nitrite plus nitrate was measured in 17 sets of breast milk and serum obtained from 17 women on postpartum day 4 or 5. RESULTS: (1) The total concentration of nitrite plus nitrate rose and peaked just before an increase in the volume of milk secreted was observed. (2) The total concentration of nitrite plus nitrate in breast milk was not correlated with that in the serum. (3) High levels of neopterin and biopterin were found in breast milk. (4) The volume of breast milk on day 5 was correlated with the total concentration of nitrite plus nitrate observed in breast milk on days 1 to 3. (5) The total concentration of nitrite plus nitrate in the breast milk of the high secretors significantly exceeded that seen in the low secretors. CONCLUSIONS: We suggest that nitric oxide is synthesized in the breast and may trigger lactation in humans.
T Iizuka; M Sasaki; K Oishi; S Uemura; M Koike; Y Minatogawa
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  131     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-01-20     Completed Date:  1998-01-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  839-43     Citation Subset:  AIM; IM    
Department of Pediatrics, Kihoku Hospital, Wakayama Medical College, Japan.
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MeSH Terms
Biological Markers / analysis
Biopterin / analysis
Breast / metabolism*
Chromatography, High Pressure Liquid
Lactation / physiology*
Milk, Human / chemistry*
Neopterin / analysis
Nitrates / analysis
Nitric Oxide / biosynthesis*
Nitrites / analysis
Postpartum Period
Reference Values
Reg. No./Substance:
0/Biological Markers; 0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide; 22150-76-1/Biopterin; 670-65-5/Neopterin

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