Document Detail

Nitric oxide maintains dilation of immature and mature collaterals in rat hindlimb.
MedLine Citation:
PMID:  8998196     Owner:  NLM     Status:  MEDLINE    
The role of nitric oxide (NO) in maintaining collateral dilation was investigated in rats with acute and chronic superficial femoral artery occlusion. Collateral function was evaluated from arterial pressure measurements proximal (mean arterial pressure, MAP) and distal (PD) to the occlusion under resting and hyperemic conditions. For resting and hyperemic conditions, respectively, PD increased with the duration of occlusion from 34 +/- 2.1 and 14 +/- 0.8 mm Hg acutely postocclusion to 37 +/- 2.8 and 19 +/- 3.6, 42 +/- 4.9 and 25 +/- 1.5, and 49 +/- 5.6 and 25 +/- 2.1 mm Hg at 1, 4, and 12 weeks. After NO synthase inhibition with N omega-nitro-L-arginine methyl ester (L-NAME), PD in control limbs increased but in occluded limbs decreased by 20 +/- 2.0 mm Hg (acute) and 18 +/- 2.1, 15 +/- 4.4, and 20 +/- 8.1 mm Hg at 1, 4, and 12 weeks postligation, respectively. The percent of MAP (%MAP) dissipated by large arteries and collateral vessels decreased during collateral development (from 71 +/- 1.7% acutely to 57 +/- 2.2% at 12 weeks postligation) and was increased approximately 20% by L-NAME at each time point. The rise in PD and decrease in %MAP dissipated by collaterals following chronic occlusion indicates that significant collateral development occurred. The fall in PD and increase in %MAP dissipation after L-NAME administration suggest that NO-mediated vasodilatory tone is maintained throughout the period of collateral development.
J L Unthank; J C Nixon; M C Dalsing
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of vascular research     Volume:  33     ISSN:  1018-1172     ISO Abbreviation:  J. Vasc. Res.     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-02-12     Completed Date:  1997-02-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  471-9     Citation Subset:  IM    
Department of Surgery, Indiana University Medical Center, Indianapolis 46202-2879, USA.
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MeSH Terms
Arterial Occlusive Diseases / physiopathology
Blood Pressure / drug effects
Hindlimb / blood supply*
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / pharmacology*
Nitric Oxide Synthase / drug effects
Rats, Sprague-Dawley
Regional Blood Flow / drug effects
Vasodilation / drug effects*
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; EC Oxide Synthase

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