Document Detail


Nitric oxide levels in preterm and term infants and in premature infants with bacteremia.
MedLine Citation:
PMID:  15237238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the serum nitric oxide levels in healthy neonates and in infants with bacteremia. METHODS: We performed a prospective study in a tertiary neonatal intensive care unit. The serum nitric oxide levels were measured in all infants at birth (basal) and in the infected neonates also on the first 2 days of bacteremia. RESULTS: Thirty-three neonates (10 term, 23 preterm) were included. Eleven preterm infants (mean gestational age 27 weeks) had bacteremia. The main blood culture isolates included coagulase-negative staphylococci (n=4), Klebsiella pneumoniae (n=3), and Escherichia coli (n=3). The serum nitric oxide levels increased during infection in 10 infants (p <0.008). The mean nitric oxide level before infection was 44 microM and during infection 96 microM (p=0.008). In the healthy babies, the mean nitric oxide level was 26 microM in those with a gestational age <27 weeks, 44 microM in those born between 28 and 36 weeks of gestation, and 63 microM in term infants. CONCLUSIONS: Bacteremic preterm infants produce significantly higher amounts of nitric oxide. The basal nitric oxide levels at birth may be correlated with gestational age.
Authors:
D Marom; Y Yuhas; L Sirota; G Livni; S Ashkenazi
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Publication Detail:
Type:  Journal Article     Date:  2004-06-25
Journal Detail:
Title:  Biology of the neonate     Volume:  86     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-01     Completed Date:  2005-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  160-4     Citation Subset:  IM    
Affiliation:
Department of Pediatrics A, Schneider Children's Medical Center of Israel, Petah Tiqwa, Israel. dmarom@clalit.org.il
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MeSH Terms
Descriptor/Qualifier:
Bacteremia / blood*,  microbiology
Enterobacter / isolation & purification
Escherichia coli / isolation & purification
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature / blood*
Infant, Premature, Diseases / blood*
Klebsiella pneumoniae / isolation & purification
Male
Nitric Oxide / blood*
Staphylococcus / isolation & purification
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide

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