| Nitric oxide levels in preterm and term infants and in premature infants with bacteremia. | |
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MedLine Citation:
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PMID: 15237238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the serum nitric oxide levels in healthy neonates and in infants with bacteremia. METHODS: We performed a prospective study in a tertiary neonatal intensive care unit. The serum nitric oxide levels were measured in all infants at birth (basal) and in the infected neonates also on the first 2 days of bacteremia. RESULTS: Thirty-three neonates (10 term, 23 preterm) were included. Eleven preterm infants (mean gestational age 27 weeks) had bacteremia. The main blood culture isolates included coagulase-negative staphylococci (n=4), Klebsiella pneumoniae (n=3), and Escherichia coli (n=3). The serum nitric oxide levels increased during infection in 10 infants (p <0.008). The mean nitric oxide level before infection was 44 microM and during infection 96 microM (p=0.008). In the healthy babies, the mean nitric oxide level was 26 microM in those with a gestational age <27 weeks, 44 microM in those born between 28 and 36 weeks of gestation, and 63 microM in term infants. CONCLUSIONS: Bacteremic preterm infants produce significantly higher amounts of nitric oxide. The basal nitric oxide levels at birth may be correlated with gestational age. |
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Authors:
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D Marom; Y Yuhas; L Sirota; G Livni; S Ashkenazi |
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Publication Detail:
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Type: Journal Article Date: 2004-06-25 |
Journal Detail:
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Title: Biology of the neonate Volume: 86 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2004 |
Date Detail:
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Created Date: 2004-10-01 Completed Date: 2005-02-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: Switzerland |
Other Details:
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Languages: eng Pagination: 160-4 Citation Subset: IM |
Affiliation:
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Department of Pediatrics A, Schneider Children's Medical Center of Israel, Petah Tiqwa, Israel. dmarom@clalit.org.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacteremia
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blood*,
microbiology Enterobacter / isolation & purification Escherichia coli / isolation & purification Female Gestational Age Humans Infant, Newborn Infant, Premature / blood* Infant, Premature, Diseases / blood* Klebsiella pneumoniae / isolation & purification Male Nitric Oxide / blood* Staphylococcus / isolation & purification |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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