Document Detail


Nitric oxide level and adenosine deaminase activity in cerebrospinal fluid of patients with subarachnoid hemorrhage.
MedLine Citation:
PMID:  18597230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Adenosine and nitric oxide (NO) are known as vasodilatators. We investigated adenosine deaminase (ADA) activity and NO concentration in the cerebrospinal fluid (CSF) of patients with subarachnoid hemorrhage (SAH). METHODS: Forty patients with SAH and 10 controls were included in the study. Nitrate level and ADA activity were measured in CSF. SAH patients were grouped according to the presence of angiographic vasospasm, Hunt and Hess grading, Glasgow Coma Scale (GCS) and Fisher Grade (FG). RESULTS: The level of NO markers in SAH patients decreased when compared to that in the control group (p < 0.05). However, NO markers in patients with vasospasm was higher than in that of patients without vasospasm (p < 0.05). ADA activity increased in patients with SAH (p < 0.01) and also patients with angiographic vasospasm (p < 0.05). ADA activity in the poor-grade SAH group was higher than that in the good-grade SAH group. The group with the lower GCS showed increased ADA activity compared to those with a higher GCS score (p < 0.01). Furthermore, patients with FG 4 had a higher level of ADA activity compared to FG 1 and 2 and FG 3 (p < 0.001 and p < 0.01, respectively). CONCLUSION: Decreased NO level may participate in the early development of vasospasm. However, the increased level of ADA activity in the SAH patients with the poor clinical and consciousness level may have resulted from the ischemic cerebral insult.
Authors:
Ramazan Durmaz; Emre Ozkara; Güngör Kanbak; Okan Can Arslan; Ali Dokumacioğlu; Kazim Kartkaya; Metin Ant Atasoy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Turkish neurosurgery     Volume:  18     ISSN:  1019-5149     ISO Abbreviation:  Turk Neurosurg     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-07-03     Completed Date:  2008-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423821     Medline TA:  Turk Neurosurg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM    
Affiliation:
Deparment of Neurosurgery, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey. rdurmaz@ogu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adenosine Deaminase / cerebrospinal fluid*
Brain Ischemia / cerebrospinal fluid,  physiopathology,  radiography
Cerebrovascular Circulation*
Female
Glasgow Coma Scale
Humans
Male
Middle Aged
Nitric Oxide / cerebrospinal fluid*
Subarachnoid Hemorrhage / cerebrospinal fluid*,  physiopathology,  radiography
Tomography, X-Ray Computed
Vasodilation / physiology*
Vasospasm, Intracranial / cerebrospinal fluid,  physiopathology,  radiography
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; EC 3.5.4.4/Adenosine Deaminase

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