Document Detail


Nitric oxide and its relationship to thrombotic disorders.
MedLine Citation:
PMID:  12871317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitric oxide (NO) is released by the endothelium preventing platelet adhesion to the vessel wall. When released by platelets, NO inhibits further recruitment of platelets to a growing thrombus. Modulation of endogenous NO release may be a mechanism by which the thrombotic response can be regulated as suggested by several clinical diseases associated with impaired bioactive NO. Diseases including atrial fibrillation and coronary atherothrombotic disease have been associated with impaired NO release or decrease in NO bioavailability.
Authors:
J E Freedman; J Loscalzo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  1     ISSN:  1538-7933     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-21     Completed Date:  2004-04-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  England    
Other Details:
Languages:  eng     Pagination:  1183-8     Citation Subset:  IM    
Affiliation:
The Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA. freedmaj@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / physiology
Blood Platelets / metabolism
Endothelium, Vascular / metabolism
Hemostasis
Humans
Nitric Oxide / physiology*
Reactive Oxygen Species / metabolism
Thrombosis / etiology*
Grant Support
ID/Acronym/Agency:
AG 08226/AG/NIA NIH HHS; HL 58976/HL/NHLBI NIH HHS; HL 61795/HL/NHLBI NIH HHS; HL 62267/HL/NHLBI NIH HHS; P50 HL 55993/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; 10102-43-9/Nitric Oxide

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