Document Detail

Nitric oxide and its effects on the calcium transport systems in the myocardium.
MedLine Citation:
PMID:  9452943     Owner:  NLM     Status:  MEDLINE    
Nitric oxide (NO) is an important modulator of many physiological processes, including myocardial contractile function. The understanding of how the production of NO in the myocardium is regulated in response to physiological stimuli and pathological processes is evolving rapidly. The main goal of this minireview is to summarize the current knowledge (i) about the enzymes that produce NO in the heart muscle, (ii) about the targets of myocardial NO that modulate calcium transport systems of the heart muscle cells, and (iii) about the role that NO-induced changes of calcium homeostasis play in the modulation of myocardial contractility.
A Zahradníková; O Krizanová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  General physiology and biophysics     Volume:  16     ISSN:  0231-5882     ISO Abbreviation:  Gen. Physiol. Biophys.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-03-12     Completed Date:  1998-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400604     Medline TA:  Gen Physiol Biophys     Country:  SLOVAKIA    
Other Details:
Languages:  eng     Pagination:  197-214     Citation Subset:  IM    
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.
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MeSH Terms
Biological Transport
Calcium / metabolism*
Myocardial Contraction
Myocardium / enzymology,  metabolism*
Nitric Oxide / physiology*
Nitric Oxide Synthase / antagonists & inhibitors,  metabolism
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7440-70-2/Calcium; EC Oxide Synthase

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