Document Detail

Nitric oxide and iron metabolism in exercised rat with L-arginine supplementation.
MedLine Citation:
PMID:  14577577     Owner:  NLM     Status:  MEDLINE    
The present study was designed to investigate whether L-arginine (Arg) supplementation in exercise affects nitric oxide (NO) synthesis in tissues and thus iron metabolism. Rats were assigned to one of four groups: EG (Exercise), SG (Sedentary), EAG (Exercise + Arg), and SAG (Sedentary + Arg). Both EG and EAG swam 2 h/day for 3 months. Both SAG and EAG received 3% Arg supplementation in their drinking water. The results showed that Arg supplementation in exercise (EAG) significantly increased nitrite and nitrate (NOx) concentration in the kidney and BMC, rather than in the liver, spleen and heart. Arg supplementation significantly increased both nonheme iron (NHI) and catalytic iron (CI) content in the kidney, to the extent that the ratio of CI/NHI or storage iron (SI)/NHI was not significantly affected, and significantly decreased NHI content and increased CI content in BMC, to the extent that SI content or SI/NHI was significantly decreased. These findings suggest that Arg supplementation in exercise, possibly through increasing NO synthesis, may change CI formation in the kidney and BMC, and affect iron storage in BMC rather than in the kidney.
De-Sheng Xiao; Lu Jiang; Li-Long Che; Liwei Lu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  252     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-27     Completed Date:  2004-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
School of Medical Technology, Jiangsu University, Jiangsu Province, Hong Kong, P R China.
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MeSH Terms
Arginine / administration & dosage*
Iron / blood,  metabolism*
Nitric Oxide / blood,  metabolism*
Physical Conditioning, Animal*
Rats, Sprague-Dawley
Reg. No./Substance:
10102-43-9/Nitric Oxide; 74-79-3/Arginine; 7439-89-6/Iron

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