Document Detail

Nitric oxide is involved in the immunomodulating activities of acidic polysaccharide from Panax ginseng.
MedLine Citation:
PMID:  11301856     Owner:  NLM     Status:  MEDLINE    
The effects of an acidic polysaccharide isolated from the ethanol-insoluble and water-soluble fraction of Panax ginseng C. A. Meyer on immunomodulating activities were investigated. A high output nitric oxide synthase (iNOS) was shown in female BALB/c mice administered intraperitoneally with the acidic polysaccharide from ginseng. Newly synthesized iNOS protein was also observed in peritoneal macrophages cultured with interferon-gamma and the acidic polysaccharide. Spleen cells from acidic polysaccharide-treated mice did not proliferate in response to concanavalin A, but restored the responsiveness by the cotreatment of NG-monomethyl-L-arginine (NMMA) with concanavalin A. The treatment of mice with aminoguanidine, a specific iNOS inhibitor, alleviated the acidic polysaccharide-induced suppression of antibody response to sheep red blood cells. Present results suggest that the immunomodulating activities of the acidic polysaccharide were mediated by the production of nitric oxide.
K M Park; Y S Kim; T C Jeong; C O Joe; H J Shin; Y H Lee; K Y Nam; J D Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  67     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-13     Completed Date:  2001-05-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Korea Ginseng & Tobacco Research Institute, Taejon, Korea.
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MeSH Terms
Adjuvants, Immunologic / isolation & purification,  pharmacology*
Antibody-Producing Cells / drug effects
Cells, Cultured / drug effects,  immunology
Concanavalin A / pharmacology
Enzyme Induction
Enzyme Inhibitors
Guanidines / toxicity
Interferon-gamma / metabolism
Mice, Inbred BALB C
Nitric Oxide / metabolism*
Nitric Oxide Synthase / antagonists & inhibitors,  metabolism
Nitric Oxide Synthase Type II
Panax / chemistry*
Plant Lectins
Plant Roots / chemistry
Plants, Medicinal*
Polysaccharides / isolation & purification,  pharmacology*
Spleen / cytology,  drug effects,  immunology
omega-N-Methylarginine / pharmacology
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Enzyme Inhibitors; 0/Guanidines; 0/Plant Lectins; 0/Polysaccharides; 10102-43-9/Nitric Oxide; 11028-71-0/Concanavalin A; 17035-90-4/omega-N-Methylarginine; 79-17-4/pimagedine; 82115-62-6/Interferon-gamma; EC Oxide Synthase; EC Oxide Synthase Type II; EC protein, mouse

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