| Nitric oxide inhibition in paraventricular nucleus on cardiovascular and autonomic modulation after exercise training in unanesthetized rats. | |
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MedLine Citation:
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PMID: 21172321 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is well known that regular physical exercise alter cardiac function and autonomic modulation of heart rate variability (HRV). The paraventricular nucleus of hypothalamus (PVN) is an important site of integration for autonomic and cardiovascular responses, where nitric oxide (NO) plays an important role. The aim of our study was to evaluate the cardiovascular parameters and autonomic modulation by means of spectral analysis after nitric oxide synthase (NOS) inhibition in the PVN in conscious sedentary (S) or swimming trained (ST) rats. After swimming training protocol, adult male Wistar rats, instrumented with guide cannulas to PVN and femoral artery and vein catheters were submitted to mean arterial pressure (MAP) and heart rate (HR) recording. At baseline, the physical training induced a resting bradycardia (S: 374±5, ST: 346±1bpm) and promoted adaptations in HRV characterized by an increase in high-frequency oscillations (HF; 26.43±6.91 to 88.96±2.44) and a decrease in low-frequency oscillations (LF; 73.57±6.91 to 11.04±2.44) in normalized units. The microinjection of N(ω)-nitro-l-arginine methyl ester (l-NAME) in the PVN of sedentary and trained rats promoted increase in MAP and HR. l-NAME in the PVN did not significantly alter the spectral parameters of HRV of sedentary animals, however in the trained rats increased LF oscillations (11.04±2.44 to 27.62±6.97) and decreased HF oscillations (88.96±2.44 to 72.38±6.97) in normalized units compared with baseline. Our results suggest that NO in the PVN may collaborate to cardiac autonomic modulation after exercise training. |
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Authors:
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Rosiane Batista Mastelari; Hugo Celso Dutra de Souza; Adriane Lenhard; Fernando Morgan de Aguiar Corrêa; Marli Cardoso Martins-Pinge |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-21 |
Journal Detail:
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Title: Brain research Volume: - ISSN: 1872-6240 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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