| Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women. | |
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MedLine Citation:
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PMID: 12817182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO), which plays an important role in natriuresis. We determined whether changes in endothelium-dependent vasodilation (EDD) and plasma ADMA predict changes in blood pressure (BP) after salt loading in normotensive postmenopausal women (PMW). METHODS: In 15 normotensive PMW (age 50-60 years), not receiving estrogen, ambulatory 24-h BP, plasma lipids, and ADMA were measured after 4 days of a low-salt diet (70 mEq/day) and following 7 days of high-salt intake (260 mEq/day). Brachial artery diameter at rest, during reactive hyperemia, i.e. EDD, and after sublingual nitroglycerin, i.e. non-EDD, were measured by ultrasound. The 24-h urinary NO metabolite (NOx) was measured by Griess reaction. Plasma ADMA was measured by high-pressure liquid chromatography. RESULTS: During low-salt, 24-h BP levels averaged 121 +/- 11 and 69 +/- 7 mmHg for systolic BP (SBP) and diastolic BP (DBP), respectively. After salt loading, average 24-h BP increases were: 7.6 mmHg for SBP, 2.2 mmHg for DBP, and 5.5 mmHg for pulse pressure (PP). Increases of 24-h SBP and 24-h PP after salt loading correlated directly with changes in ADMA (partial R2 = 0.16 for 24-h SBP and 0.17 for 24-h PP, P < 0.05 for both) and inversely with changes in EDD (partial R2 = 0.13, P = 0.09 for 24 h SBP and partial R2 = 0.15, P = 0.07 for 24-h PP), after adjustment for age and cholesterol. CONCLUSIONS: Inhibition of NO bioavailability by ADMA and a subsequent reduction in EDD contribute to the increase in BP during high-salt intake in normotensive PMW not receiving estrogen. |
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Authors:
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Angelo Scuteri; Markus C Stuehlinger; John P Cooke; Jeanette G Wright; Edward G Lakatta; David E Anderson; Jerome L Fleg |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of hypertension Volume: 21 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-20 Completed Date: 2004-04-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1339-46 Citation Subset: IM |
Affiliation:
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Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, Maryland, USA. angeloelefante@interfree.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arginine
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analogs & derivatives*,
blood* Blood Pressure / drug effects, physiology* Brachial Artery / physiology Endothelium, Vascular / metabolism Female Humans Middle Aged Natriuresis / drug effects, physiology Nitric Oxide / blood* Postmenopause / metabolism* Predictive Value of Tests Regression Analysis Sodium Chloride, Dietary / administration & dosage* Vasodilation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL-58638/HL/NHLBI NIH HHS; R01 HL-63685/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sodium Chloride, Dietary; 10102-43-9/Nitric Oxide; 30315-93-6/N,N-dimethylarginine; 74-79-3/Arginine |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2003 Jul;21(7):1255-7
[PMID:
12817168
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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