Document Detail

Nitric oxide inhalation is useful in the management of right ventricular failure caused by myocardial contusion.
MedLine Citation:
PMID:  15752412     Owner:  NLM     Status:  MEDLINE    
We report a severe head injury and blunt chest trauma with sternal and multiple rib fractures with high-energy impact in a 22-year-old man. Twelve hours after the accident, haemodynamic status of the patient rapidly worsened because of right ventricular (RV) failure due to myocardial contusion, requiring increasing doses of catecholamine. Nitric oxide inhalation was used to decrease RV afterload, and produced an immediate improvement in haemodynamic status, permitting a decrease in catecholamine administration. From days 2 through 8, cardiac function continued to improve, and was normal on day 9. Nitric oxide inhalation was stopped on day 4.
E Meaudre; P Goutorbe; H Boret; E Kaiser; L Salinier; E Cantais; B Palmier
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  49     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-08     Completed Date:  2005-09-22     Revised Date:  2010-12-23    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  415-7     Citation Subset:  IM    
Intensive Care Unit, Military Teaching Hospital, Hôpital d'Instruction des Armées Sainte Anne, 83800 Toulon-Naval, France.
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MeSH Terms
Accidents, Traffic
Administration, Inhalation
Bronchodilator Agents / administration & dosage,  therapeutic use*
Catecholamines / therapeutic use
Contusions / complications*,  drug therapy,  etiology
Dose-Response Relationship, Drug
Electrocardiography / methods
Epinephrine / therapeutic use
Fatal Outcome
Head Injuries, Closed / etiology
Heart Injuries / complications*,  drug therapy,  etiology
Hemodynamics / drug effects
Nitric Oxide / administration & dosage,  therapeutic use*
Norepinephrine / therapeutic use
Respiratory Distress Syndrome, Adult / complications
Vasoconstrictor Agents / therapeutic use
Ventricular Dysfunction, Right / drug therapy*,  etiology*
Wounds, Nonpenetrating / complications
Reg. No./Substance:
0/Bronchodilator Agents; 0/Catecholamines; 0/Vasoconstrictor Agents; 10102-43-9/Nitric Oxide; 51-41-2/Norepinephrine; 51-43-4/Epinephrine
Comment In:
Cardiol J. 2010;17(6):655; author reply 656   [PMID:  21154278 ]

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