| Nitric oxide inhalation therapy in very low-birthweight infants with hypoplastic lung due to oligohydramnios. | |
| | |
MedLine Citation:
|
PMID: 15043657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Although nitric oxide inhalation (iNO) therapy improves arterial oxygenation and reduces the rate of extracorporeal membrane oxygenation in term neonates, the efficacy of this therapy in premature infants is controversial. The objective of the present study was to determine whether iNO therapy improves the survival of very low-birthweight infants with pulmonary hypoplasia due to prolonged rupture of membrane. METHODS: A retrospective comparative study of very low-birthweight infants with pulmonary hypoplasia due to oligohydramnios who had or had not been treated with iNO therapy, was performed (iNO-treated group, eight infants; control group, 10 infants). A neonate was considered to have pulmonary hypoplasia due to oligohydramnios if the following conditions were satisfied: (i) artificial surfactant treatment did not improve the respiratory distress; (ii) prolonged rupture of membrane (PROM) continued for more than 5 days with oligohydramnios; and (iii) sufficient arterial oxygenation did not occur even after giving 100% oxygen, and more than 8 cm H(2)O of mean airway pressure was needed to maintain arterial oxygenation. RESULTS: Nitric oxide inhalation improved arterial oxygenation rapidly and consistently in all eight infants with pulmonary hypoplasia. All eight iNO-treated infants survived longer than 28 days, while five of the 10 control infants died within 24 h of birth (P < 0.05). Before starting iNO, seven of the eight treated infants had shown persistent pulmonary hypertension, which was confirmed by echocardiography. No iNO-treated infant had IVH greater than grade 1, while one control infant had grade 2 IVH. All six long-term survivors in the iNO-treated group are developing normally, while only two of the control infants are developing normally as of February 2002. CONCLUSIONS: The majority of the infants with pulmonary hypoplasia due to oligohydramnios had persistent pulmonary hypertension. iNO improved the arterial oxygenation and significantly improved the survival rate. A controlled study to determine whether iNO therapy improves the survival rate of preterm infants with pulmonary hypoplasia due to oligohydramnios is necessary. |
| | |
Authors:
|
Naoki Uga; Tetsuya Ishii; Yasuhiro Kawase; Hiroko Arai; Hiroshi Tada |
Related Documents
:
|
264077 - Bilateral renal agenesis (potter's syndrome) in two consecutive infants. 19496127 - Balloon dilation of pulmonary valve stenosis in infants less than 3 kg: a 20-year exper... 339007 - Total anomalous pulmonary venous connection. long-term results following repair in infa... 969827 - Oesophageal phlebectasis in an infant with pulmonary venous obstruction owing to a cong... 15590437 - Neonatal seizures in preterm infants: clinical outcome and relationship with subsequent... 3337347 - Neonatal neurobehavior after epidural anesthesia for cesarean section: a comparison of ... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: 46 ISSN: 1328-8067 ISO Abbreviation: Pediatr Int Publication Date: 2004 Feb |
Date Detail:
|
Created Date: 2004-03-26 Completed Date: 2004-04-21 Revised Date: 2008-05-21 |
Medline Journal Info:
|
Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: Australia |
Other Details:
|
Languages: eng Pagination: 10-4 Citation Subset: IM |
Affiliation:
|
Division of Neonatology, Perinatal Center, Toho University School of Medicine, Tokyo, Japan. naokiuga@med.toho-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Asphyxia Neonatorum / etiology, mortality, therapy* Bronchodilator Agents / therapeutic use* Female Humans Infant, Newborn Infant, Very Low Birth Weight* Japan / epidemiology Lung / abnormalities* Nitric Oxide / therapeutic use* Oligohydramnios / complications Pregnancy Retrospective Studies Survival Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Bronchodilator Agents; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determination of total homocysteine in dried blood spots using high performance liquid chromatograph...
Next Document: Sucking behavior at breast during the early newborn period affects later breast-feeding rate and dur...