| Nitric oxide induced cervical ripening in the human: Involvement of cyclic guanosine monophosphate, prostaglandin F(2 alpha), and prostaglandin E(2). | |
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MedLine Citation:
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PMID: 11967501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of the study was to investigate possible mechanisms and morphologic changes involved in nitric oxide-induced cervical ripening. STUDY DESIGN: Women scheduled for surgical termination of first trimester pregnancy were randomized to 1 of 3 groups: isosorbide 5-mononitrate 40 mg 4 hours or 10 hours before the operation or no preoperative treatment. Cervical specimens were obtained for the analysis of tissue levels of cyclic guanosine monophosphate, cyclic adenosine monophosphate, cyclo-oxygenase 1, cyclo-oxygenase 2, prostaglandin F(2 alpha), and prostaglandin E(2) or were fixed in glutaraldehyde for microscopy. RESULTS: Increased levels of cyclic guanosine monophosphate, cyclo-oxygenase 2, prostaglandin F(2 alpha), and prostaglandin E(2) were found in samples that were exposed to isosorbide 5-mononitrate compared with control samples. Electron microscopy revealed stromal edema and collagen disorganization after isosorbide 5-mononitrate treatment. CONCLUSION: Cyclic guanosine monophosphate, prostaglandin F(2 alpha), and prostaglandin E(2) are involved in nitric oxide-induced cervical ripening. Nitric oxide causes morphologic changes similar to those changes seen during spontaneous cervical ripening. |
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Authors:
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E Ekerhovd; B Weijdegård; M Brännström; I Mattsby-Baltzer; A Norström |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 186 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-22 Completed Date: 2002-06-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 745-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Göteborg University, Sweden. erling.ekerhovd@obgyn.gu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cervical Ripening* Cervix Uteri / anatomy & histology, chemistry, drug effects Cyclic AMP / analysis Cyclic GMP / analysis, physiology* Cyclooxygenase 1 Cyclooxygenase 2 Dinoprost / analysis, physiology* Dinoprostone / analysis, physiology* Female Gestational Age Humans Immunoblotting Isoenzymes / analysis Isosorbide Dinitrate / administration & dosage, analogs & derivatives, pharmacology Membrane Proteins Microscopy, Electron Nitric Oxide / physiology* Nitric Oxide Donors / administration & dosage, pharmacology Pregnancy Prostaglandin-Endoperoxide Synthases / analysis |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 0/Membrane Proteins; 0/Nitric Oxide Donors; 10102-43-9/Nitric Oxide; 16051-77-7/isosorbide-5-mononitrate; 363-24-6/Dinoprostone; 551-11-1/Dinoprost; 60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP; 87-33-2/Isosorbide Dinitrate; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS1 protein, human; EC 1.14.99.1/PTGS2 protein, human; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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