Document Detail


Nitric oxide in the human respiratory cycle.
MedLine Citation:
PMID:  12042776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interactions of nitric oxide (NO) with hemoglobin (Hb) could regulate the uptake and delivery of oxygen (O(2)) by subserving the classical physiological responses of hypoxic vasodilation and hyperoxic vasconstriction in the human respiratory cycle. Here we show that in in vitro and ex vivo systems as well as healthy adults alternately exposed to hypoxia or hyperoxia (to dilate or constrict pulmonary and systemic arteries in vivo), binding of NO to hemes (FeNO) and thiols (SNO) of Hb varies as a function of HbO(2) saturation (FeO(2)). Moreover, we show that red blood cell (RBC)/SNO-mediated vasodilator activity is inversely proportional to FeO(2) over a wide range, whereas RBC-induced vasoconstriction correlates directly with FeO(2). Thus, native RBCs respond to changes in oxygen tension (pO2) with graded vasodilator and vasoconstrictor activity, which emulates the human physiological response subserving O(2) uptake and delivery. The ability to monitor and manipulate blood levels of NO, in conjunction with O(2) and carbon dioxide, may therefore prove useful in the diagnosis and treatment of many human conditions and in the development of new therapies. Our results also help elucidate the link between RBC dyscrasias and cardiovascular morbidity.
Authors:
Timothy J McMahon; Richard E Moon; Ben P Luschinger; Martha S Carraway; Anne E Stone; Bryant W Stolp; Andrew J Gow; John R Pawloski; Paula Watke; David J Singel; Claude A Piantadosi; Jonathan S Stamler
Related Documents :
4632136 - Rickettsial hemolysis: adsorption of rickettsiae to erythrocytes.
1884706 - Exercise induced hormonal and metabolic changes in thoroughbred horses: effects of cond...
1592716 - Changes in plasma and erythrocyte k+ during hypercapnia and different grades of exercis...
25447446 - The effects of high doses of nandrolone decanoate and exercise on prostate microvascula...
19149376 - Effects of emersion-induced hypoxia on some haemolymph constituents of nephrops norvegi...
10606216 - Metabolic and cardiocirculatory reactions after concentric and eccentric exercise of th...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2002-06-03
Journal Detail:
Title:  Nature medicine     Volume:  8     ISSN:  1078-8956     ISO Abbreviation:  Nat. Med.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-01     Completed Date:  2002-08-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9502015     Medline TA:  Nat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  711-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anoxia / physiopathology
Erythrocytes / physiology
Hemodynamics / physiology*
Hemoglobins / metabolism*
Humans
Hyperoxia / physiopathology
Nitric Oxide / physiology*
Oxygen / blood
Respiratory Mechanics*
Respiratory System / blood supply*
Vasoconstriction
Vasodilation
Grant Support
ID/Acronym/Agency:
HL04424-09/HL/NHLBI NIH HHS; K08 HL04014/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins; 10102-43-9/Nitric Oxide; 7782-44-7/Oxygen
Comments/Corrections
Comment In:
Nat Med. 2003 May;9(5):481-2; author reply 482-3   [PMID:  12724738 ]
Nat Med. 2002 Jul;8(7):657-8   [PMID:  12091894 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The genetic consequences of our sweet tooth.
Next Document:  siRNA-directed inhibition of HIV-1 infection.