Document Detail


Nitric oxide in the control of luminescence from lantern shark (Etmopterus spinax) photophores.
MedLine Citation:
PMID:  20709929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Photophores (photogenic organs) of the lantern shark Etmopterus spinax are under hormonal control, with prolactin (PRL) and melatonin (MT) triggering the light emission. Differential sensitivity to these hormones in adult individuals suggests, however, that the luminescence of this shark is controlled by an additional mechanism. In this study, different techniques were used to investigate a potential modulator of E. spinax luminescence - nitric oxide (NO). NO synthase (NOS)-like immunoreactivity (IR) was found in the photocytes (photogenic cells) of the photophores. In addition, acetylated tubulin IR also supported the presence of nerves running through the photogenic tissue and innervating different structural elements of the photophores: photocytes, pigmented cells from the iris-like structure and lens cells. Pharmacological experiments confirmed a modulatory action of NO on the hormonally induced luminescence: NO donors sodium nitroprusside (SNP) and hydroxylamine decreased the time to reach the maximum amplitude (TL(max)) of MT-induced luminescence while these substances decreased the maximum amplitude of PRL-induced luminescence (and also the TL(max) in the case of SNP). The small impact of the NOS inhibitor l-NAME on hormonally induced luminescence suggests that NO is only produced on demand. The cGMP analogue 8BrcGMP mimicked the effects of NO donors suggesting that the effects of NO are mediated by cGMP.
Authors:
Julien M Claes; Jenny Krönström; Susanne Holmgren; Jérôme Mallefet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  213     ISSN:  1477-9145     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-11-24     Revised Date:  2011-01-06    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3005-11     Citation Subset:  IM    
Affiliation:
Laboratory of Marine Biology, Earth and Life Institute, Université catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium. julien.m.claes@uclouvain.be
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MeSH Terms
Descriptor/Qualifier:
Animal Structures / cytology,  embryology,  enzymology,  metabolism*
Animals
Cyclic GMP / analogs & derivatives,  metabolism,  pharmacology
Embryo, Nonmammalian
Enzyme Inhibitors / pharmacology
Guanylate Cyclase / antagonists & inhibitors
Hydroxylamine / pharmacology
Immunohistochemistry
Luminescence*
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / metabolism*
Nitric Oxide Donors / pharmacology
Nitric Oxide Synthase / antagonists & inhibitors
Nitroprusside / pharmacology
Oxadiazoles / pharmacology
Quinoxalines / pharmacology
Sharks / anatomy & histology*,  embryology,  metabolism*
Signal Transduction / drug effects
Spectrum Analysis
Chemical
Reg. No./Substance:
0/1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; 0/Enzyme Inhibitors; 0/Nitric Oxide Donors; 0/Oxadiazoles; 0/Quinoxalines; 10102-43-9/Nitric Oxide; 15078-28-1/Nitroprusside; 31356-94-2/8-bromocyclic GMP; 50903-99-6/NG-Nitroarginine Methyl Ester; 7665-99-8/Cyclic GMP; 7803-49-8/Hydroxylamine; EC 1.14.13.39/Nitric Oxide Synthase; EC 4.6.1.2/Guanylate Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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