| Nitric oxide in children with persistent asthma. | |
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MedLine Citation:
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PMID: 16683051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the difference in exhaled nitric oxide levels in atopic and nonatopic asthmatic patients treated with anti-inflammatory drugs, and to compare exhaled nitric oxide measurement with lung function tests. METHODS: Cross-sectional study with 45 consecutively selected patients with moderate and severe persistent asthma, aged between 6 and 17 years, and treated with anti-inflammatory drugs for at least 1 year. The patients were split into two groups: atopic ones (with positive skin tests) and nonatopic ones. The clinical and functional assessments and the measurement of exhaled nitric oxide were carried out concomitantly. RESULTS: There was a male predominance (62.5%), with an age range between 6 and 13 years (mean of 10.4 years) in 85% of the patients. Neither the symptoms associated with asthma (p = 0.07), allergic rhinitis (p = 0.17), food allergy (p = 0.09), necessity of systemic corticosteroids (p = 0.10), antileukotrienes (p = 0.20) and antihistamines (p = 0.70), nor the three parameters used to assess lung function (FEV(1), FEV(1)/FVC and FEF(25-75%), p > or = 0.14) were statistically significant. The frequency of eczema (p < 0.005) and exhaled nitric oxide levels (p < 0.001) were higher among atopic patients. CONCLUSION: Results suggest that clinical and functional stability of asthma among atopic patients does not necessarily reflect an efficient control over the inflammatory process and a higher probability for recurrence after discontinuation of anti-inflammatory therapy. |
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Authors:
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Nulma S Jentzsch; Muriel le Bourgeois; Jacques de Blic; Pierre Scheinmann; Serge Waernessyckle; Paulo A M Camargos |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-05-02 |
Journal Detail:
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Title: Jornal de pediatria Volume: 82 ISSN: 0021-7557 ISO Abbreviation: J Pediatr (Rio J) Publication Date: 2006 May-Jun |
Date Detail:
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Created Date: 2006-06-14 Completed Date: 2006-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985188R Medline TA: J Pediatr (Rio J) Country: Brazil |
Other Details:
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Languages: eng Pagination: 193-6 Citation Subset: IM |
Affiliation:
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Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adolescent Asthma / drug therapy*, metabolism, physiopathology Bronchodilator Agents / administration & dosage*, analysis Chi-Square Distribution Child Cross-Sectional Studies Female Humans Male Nitric Oxide / analysis* Respiration* Respiratory Function Tests Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
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J Pediatr (Rio J). 2006 May-Jun;82(3):168-70
[PMID:
16773173
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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