Document Detail

Nitric oxide in children with persistent asthma.
MedLine Citation:
PMID:  16683051     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the difference in exhaled nitric oxide levels in atopic and nonatopic asthmatic patients treated with anti-inflammatory drugs, and to compare exhaled nitric oxide measurement with lung function tests. METHODS: Cross-sectional study with 45 consecutively selected patients with moderate and severe persistent asthma, aged between 6 and 17 years, and treated with anti-inflammatory drugs for at least 1 year. The patients were split into two groups: atopic ones (with positive skin tests) and nonatopic ones. The clinical and functional assessments and the measurement of exhaled nitric oxide were carried out concomitantly. RESULTS: There was a male predominance (62.5%), with an age range between 6 and 13 years (mean of 10.4 years) in 85% of the patients. Neither the symptoms associated with asthma (p = 0.07), allergic rhinitis (p = 0.17), food allergy (p = 0.09), necessity of systemic corticosteroids (p = 0.10), antileukotrienes (p = 0.20) and antihistamines (p = 0.70), nor the three parameters used to assess lung function (FEV(1), FEV(1)/FVC and FEF(25-75%), p > or = 0.14) were statistically significant. The frequency of eczema (p < 0.005) and exhaled nitric oxide levels (p < 0.001) were higher among atopic patients. CONCLUSION: Results suggest that clinical and functional stability of asthma among atopic patients does not necessarily reflect an efficient control over the inflammatory process and a higher probability for recurrence after discontinuation of anti-inflammatory therapy.
Nulma S Jentzsch; Muriel le Bourgeois; Jacques de Blic; Pierre Scheinmann; Serge Waernessyckle; Paulo A M Camargos
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-02
Journal Detail:
Title:  Jornal de pediatria     Volume:  82     ISSN:  0021-7557     ISO Abbreviation:  J Pediatr (Rio J)     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-06-14     Completed Date:  2006-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985188R     Medline TA:  J Pediatr (Rio J)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brasil.
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MeSH Terms
Administration, Inhalation
Asthma / drug therapy*,  metabolism,  physiopathology
Bronchodilator Agents / administration & dosage*,  analysis
Chi-Square Distribution
Cross-Sectional Studies
Nitric Oxide / analysis*
Respiratory Function Tests
Sex Factors
Reg. No./Substance:
0/Bronchodilator Agents; 10102-43-9/Nitric Oxide
Comment In:
J Pediatr (Rio J). 2006 May-Jun;82(3):168-70   [PMID:  16773173 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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