Document Detail

Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity.
MedLine Citation:
PMID:  17882254     Owner:  NLM     Status:  MEDLINE    
At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.
Vittorio Calabrese; Cesare Mancuso; Menotti Calvani; Enrico Rizzarelli; D Allan Butterfield; Anna Maria Giuffrida Stella
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  8     ISSN:  1471-0048     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2007-10-16     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  766-75     Citation Subset:  IM    
Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy.
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MeSH Terms
Central Nervous System / pathology,  physiology*
Neurodegenerative Diseases / metabolism*,  prevention & control
Neuroprotective Agents / metabolism*,  therapeutic use
Neurotoxicity Syndromes / metabolism,  prevention & control
Nitric Oxide / physiology*,  therapeutic use,  toxicity
Grant Support
Reg. No./Substance:
0/Neuroprotective Agents; 10102-43-9/Nitric Oxide

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