| Nitric oxide and human umbilical vessels: pharmacological and immunohistochemical studies. | |
| | |
MedLine Citation:
|
PMID: 7638109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Human umbilical vessels are devoid of nerves and therefore endothelial cells may play an important role in the control of fetoplacental blood flow. In this study we examined the pharmacological effects of various substances, known to produce endothelial-mediated vasodilation in many blood vessels, on the human umbilical artery and vein from legal terminations [mean gestational age, 15 (8-17) weeks; n = 12] and normal term vaginal deliveries [mean gestational age, 39 (38-41) weeks; n = 12]. Acetylcholine, adenosine 5'-triphosphate, the calcium ionophore A23187 and substance P had no effect on raised vascular tone, whereas sodium nitroprusside relaxed 5-hydroxytryptamine (5-HT) preconstricted, umbilical artery and vein from both early and late pregnancy. L-NG-Nitroarginine methyl ester (L-NAME) had no effect on basal tone or on high tone, after it was raised by 5-HT. Localization of nitric oxide synthase [NOS, type I (neuronal)] was examined in the same umbilical vessels using electron immunocytochemistry. No NOS-immunoreactive endothelial cells were observed in the umbilical vessels taken during early pregnancy. However, the percentage of NOS-immunoreactive endothelial cells in umbilical artery and vein from late pregnancy was 3 and 10 per cent, respectively. These results suggest that nitric oxide contributes little, if any, to the local control of umbilical blood flow throughout pregnancy, despite the presence of NOS-immunoreactivity in a subpopulation of endothelial cells in late pregnancy. |
| | |
Authors:
|
A J Sexton; A Loesch; M Turmaine; S Miah; G Burnstock |
Related Documents
:
|
9389829 - The predictive value of uterine artery blood flow measurements for uterine receptivity ... 10428519 - Administration of low-dose aspirin to mothers with small for gestational age fetuses an... 8880629 - Doppler velocimetry of different sections of the fetal middle cerebral artery in relati... 1992689 - Investigation of placental circulations by color doppler ultrasonography. 2584899 - Percutaneous umbilical cord blood sampling. 12796939 - The acardiac twin: a case report using color doppler ultrasonography. 6477849 - Should a paediatrician be present at non-rotational forceps deliveries? 9604539 - Amoebic liver abscess in pregnancy: report of two cases. 8671509 - Combined intra-uterine and extra-uterine pregnancy associated with mild hyperstimulatio... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Placenta Volume: 16 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 1995 Apr |
Date Detail:
|
Created Date: 1995-09-11 Completed Date: 1995-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8006349 Medline TA: Placenta Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 277-88 Citation Subset: IM |
Affiliation:
|
Department of Anatomy and Developmental Biology, University College London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Endothelium, Vascular
/
drug effects* Female Gestational Age Humans Immunohistochemistry Nitric Oxide / analysis* Pregnancy Umbilical Arteries / chemistry, drug effects* Umbilical Veins / chemistry, drug effects* Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression of desmin and vimentin intermediate filaments in human decidual cells during first trimes...
Next Document: Volume-activated amino acid efflux from term human placental tissue: stimulation of efflux via a pat...