| Nitric oxide and human thermal injury short term outcome. | |
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MedLine Citation:
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PMID: 9677022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide (NO) is an important mediator in numerous physiological and pathophysiological events. After thermal injury an increase in plasma and urinary levels has been observed. The real importance of this fact is unknown. The stable NO derivatives (NO2-/NO3-) plasma concentrations were determined in 27 burned patients admitted to the Burn Unit at Santa Maria Hospital in Lisbon at first, third, fifth, seventh, ninth and 15th days and the values were compared with healthy controls (n=9). A significant increase (P<0.05) in burn patient determinations upon admission was found. The patients with inhalation injury revealed greater values compared to the other patients with statistical significance at 5th day (P<0.05). The patients who died showed a NO increase (0.397+/-0.138 vs. 0.267+/-0.017, P> 0.1, day 1) with significance at day 5 (0.615+/-0.223 vs. 0.154+/-0.048, P<0.05). The determinations in patients with sepsis were higher than in the other patients (P<0.01) at day 3. No relation with total burned surface area (TBSA) was found. For the first time, considering burned patients, a significant increase of NO was found in patients who died, in patients with inhalation injury and in patients in sepsis. The possible role of NO in burn injury is discussed. The authors suggest the possible role of NO determination as an indicator of sepsis. The role of NO synthesis inhibitors is discussed. Further studies are needed to clarify these questions. |
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Authors:
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M do Rosário Caneira da Silva; H Mota Filipe; R M Pinto; Salaverría Timóteo de Carval; M M Godinho de Matos; A Cordeiro Ferreira; J M Toscano Rico |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 24 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-09-21 Completed Date: 1998-09-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 207-12 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculdade de Medicina de Lisboa, Hospital de Santa Maria, Lisbon, Portugal. caneira@esoterica.pt |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Biological Markers / blood Burns / blood*, mortality Follow-Up Studies Humans Middle Aged Nitrates / blood Nitric Oxide / blood* Nitrites / blood Prognosis Trauma Severity Indices |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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