Document Detail

Nitric oxide generation, tachyphylaxis and cross-tachyphylaxis from nitrovasodilators in vivo.
MedLine Citation:
PMID:  10607869     Owner:  NLM     Status:  MEDLINE    
Nitric oxide (NO) increments in exhaled air and changes in mean arterial pressure of anaesthetised rabbits were measured in order to study the NO generation from NO donors and tachyphylaxis in NO formation from nitroglycerin. Continuous infusions of isosorbide dinitrate, isosorbide-5-mononitrate and 3-morpholino-sydnonimine (SIN-1) evoked dose-dependent increases in exhaled NO, paralleled by decrements in mean arterial pressure. Repeated infusions of nitroglycerin resulted in attenuation (P<0.01) of the NO increase from a given dose. Concurrent infusions of isosorbide dinitrate, isosorbide-5-mononitrate or nitroglycerin reduced the amount of NO emanating from the bioconversion of a given dose nitroglycerin as measured in the expired air (P<0.01 for all drugs), indicating cross-tachyphylaxis. SIN-1 did not exhibit such cross-tachyphylaxis. In conclusion, measurements of exhaled NO can be a useful tool for exploration of nitrovasodilator tachyphylaxis. Cross-tachyphylaxis is only shared between some nitrovasodilators and is possibly not due to feedback from the generated NO.
P Agvald; L C Adding; L E Gustafsson; M G Persson
Related Documents :
24471129 - Effects of a pre-exercise meal on plasma growth hormone response and fat oxidation duri...
7377099 - Submaximal exercise testing after unstable angina.
7127369 - The beneficial effect of diltiazem on exercise-induced st depression, measured by body ...
12177659 - Effectiveness of a novel serotonin blocker, sarpogrelate, for patients with angina pect...
3294189 - Antianginal efficacy of gallopamil in comparison to nifedipine.
1894759 - Comparison of the effect of isosorbide-5-mononitrate and isosorbide dinitrate in a slow...
6721269 - Asthma induced by suggestion: is it due to airway cooling?
17654559 - Comparative efficacy of repetitive nerve stimulation, exercise, and cold in differentia...
24661939 - Biological basis of neuroprotection and neurotherapeutic effects of whole body periodic...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  385     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-17     Completed Date:  2000-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
Department of Physiology and Pharmacology, Division of Physiology, Karolinska Institute, S-171 77, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Isosorbide Dinitrate / analogs & derivatives,  pharmacology
Molsidomine / analogs & derivatives,  pharmacology
Nitric Oxide / biosynthesis*
Nitric Oxide Donors / pharmacology*
Nitroglycerin / pharmacology
Tachyphylaxis / physiology*
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Nitric Oxide Donors; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 16051-77-7/isosorbide-5-mononitrate; 25717-80-0/Molsidomine; 33876-97-0/3-morpholino-sydnonimine; 55-63-0/Nitroglycerin; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Potentiation of the hypotensive effect of adrenomedullin in pregnant rats.
Next Document:  Positive inotropy of calcitonin gene-related peptide and amylin on porcine isolated myocardium.