Document Detail


Nitric oxide generation, tachyphylaxis and cross-tachyphylaxis from nitrovasodilators in vivo.
MedLine Citation:
PMID:  10607869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitric oxide (NO) increments in exhaled air and changes in mean arterial pressure of anaesthetised rabbits were measured in order to study the NO generation from NO donors and tachyphylaxis in NO formation from nitroglycerin. Continuous infusions of isosorbide dinitrate, isosorbide-5-mononitrate and 3-morpholino-sydnonimine (SIN-1) evoked dose-dependent increases in exhaled NO, paralleled by decrements in mean arterial pressure. Repeated infusions of nitroglycerin resulted in attenuation (P<0.01) of the NO increase from a given dose. Concurrent infusions of isosorbide dinitrate, isosorbide-5-mononitrate or nitroglycerin reduced the amount of NO emanating from the bioconversion of a given dose nitroglycerin as measured in the expired air (P<0.01 for all drugs), indicating cross-tachyphylaxis. SIN-1 did not exhibit such cross-tachyphylaxis. In conclusion, measurements of exhaled NO can be a useful tool for exploration of nitrovasodilator tachyphylaxis. Cross-tachyphylaxis is only shared between some nitrovasodilators and is possibly not due to feedback from the generated NO.
Authors:
P Agvald; L C Adding; L E Gustafsson; M G Persson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  385     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-17     Completed Date:  2000-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, Division of Physiology, Karolinska Institute, S-171 77, Stockholm, Sweden. per.agvald@fyfa.ki.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Female
Isosorbide Dinitrate / analogs & derivatives,  pharmacology
Male
Molsidomine / analogs & derivatives,  pharmacology
Nitric Oxide / biosynthesis*
Nitric Oxide Donors / pharmacology*
Nitroglycerin / pharmacology
Rabbits
Tachyphylaxis / physiology*
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Nitric Oxide Donors; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 16051-77-7/isosorbide-5-mononitrate; 25717-80-0/Molsidomine; 33876-97-0/3-morpholino-sydnonimine; 55-63-0/Nitroglycerin; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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