| Nitric oxide formation contributes to beta-adrenergic dilation of epicardial coronary arteries in response to intravenous administration of dobutamine in dogs. | |
MedLine Citation:
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PMID: 15315177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the role of nitric oxide in the beta-adrenergic vasodilation of epicardial coronary arteries in dogs, 12 dogs were instrumented for measurement of left anterior descending coronary artery diameter by transthoracic echocardiography before and after dobutamine (5 microg/kg/min IV) with and without intracoronary infusion of NG-monomethyl-L-arginine (L-NMMA) (1 mg/kg). In all 12 dogs, the diameter of left anterior descending coronary artery increased significantly from 2.35 +/- 0.25 mm to 2.59 +/- 0.24 mm (P<0.001) after dobutamine administration. In 6 of the 12 dogs, the percent change in left anterior descending coronary artery diameter induced by dobutamine decreased significantly from 12.5% +/- 8.6% to -1.5% +/- 5.4% (P<0.05) after the administration of intracoronary L-NMMA (1 mg/kg for 5 min) to block nitric oxide synthesis from L-arginine. The study demonstrated that nitric oxide formation contributes to the beta-adrenergic dilatory response of epicardial coronary arteries to dobutamine in dogs. |
Authors:
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Haoyi Yang; Youbin Deng; Xiaojun Bi; Qing Chang; Jiao Bai; Min Pan; Huijuan Xiang; Hongyun Liu; Xiulan Li; Yani Liu; Chunlei Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban Volume: 24 ISSN: 1672-0733 ISO Abbreviation: J. Huazhong Univ. Sci. Technol. Med. Sci. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-08-18 Completed Date: 2006-05-03 Revised Date: 2006-12-14 |
Medline Journal Info:
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Nlm Unique ID: 101169627 Medline TA: J Huazhong Univ Sci Technolog Med Sci Country: China |
Other Details:
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Languages: eng Pagination: 189-91 Citation Subset: IM |
Affiliation:
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Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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pharmacology Animals Coronary Vessels / physiology* Dobutamine / pharmacology* Dogs Echocardiography Female Male Nitric Oxide / physiology* Receptors, Adrenergic, beta / physiology* Vasodilation / physiology* omega-N-Methylarginine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Receptors, Adrenergic, beta; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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