Document Detail


Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation.
MedLine Citation:
PMID:  16424008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Widespread expression of the alpha-subunit of hypoxia-inducible factor (HIF-1alpha) was observed in samples of human oral squamous cell carcinoma. In all the cases, this was accompanied by a widespread distribution of nitric oxide (NO) synthases (NOS). Furthermore, in three human cell lines derived from human oral squamous cell carcinoma, the accumulation of HIF-1alpha was prevented either by inhibition of NOS activity with the nonspecific NOS inhibitor N(G)-monomethyl-L-arginine or by the antioxidants N-acetyl-L-cysteine and ascorbic acid. We suggest that, in certain forms of cancer, NO might be responsible for the accumulation of HIF-1alpha by a mechanism dependent on free radicals.
Authors:
Marisol Quintero; Peter A Brennan; Gareth J Thomas; Salvador Moncada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  66     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-20     Completed Date:  2006-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  770-4     Citation Subset:  IM    
Affiliation:
The Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, London WC1E 6BT, UK.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / physiopathology*
Free Radicals*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis,  physiology*
Immunohistochemistry
Mouth Neoplasms / physiopathology*
Nitric Oxide / toxicity*
Nitric Oxide Synthase / biosynthesis,  physiology
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 10102-43-9/Nitric Oxide; EC 1.14.13.39/Nitric Oxide Synthase

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