Document Detail

Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation.
MedLine Citation:
PMID:  16424008     Owner:  NLM     Status:  MEDLINE    
Widespread expression of the alpha-subunit of hypoxia-inducible factor (HIF-1alpha) was observed in samples of human oral squamous cell carcinoma. In all the cases, this was accompanied by a widespread distribution of nitric oxide (NO) synthases (NOS). Furthermore, in three human cell lines derived from human oral squamous cell carcinoma, the accumulation of HIF-1alpha was prevented either by inhibition of NOS activity with the nonspecific NOS inhibitor N(G)-monomethyl-L-arginine or by the antioxidants N-acetyl-L-cysteine and ascorbic acid. We suggest that, in certain forms of cancer, NO might be responsible for the accumulation of HIF-1alpha by a mechanism dependent on free radicals.
Marisol Quintero; Peter A Brennan; Gareth J Thomas; Salvador Moncada
Related Documents :
20142808 - Cytopathology by optical methods: spectral cytopathology of the oral mucosa.
2447698 - Characterization of subcolumnar reserve cells and other epithelia of human uterine cerv...
9223658 - Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins:...
17949348 - Polyploidization of 2nh1 (es) cells by k-252a and staurosporine.
6153078 - Movement of calcium ions and release of histamine from rat mast cells.
23318878 - Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cell...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  66     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-20     Completed Date:  2006-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  770-4     Citation Subset:  IM    
The Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, London WC1E 6BT, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carcinoma, Squamous Cell / physiopathology*
Free Radicals*
Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis,  physiology*
Mouth Neoplasms / physiopathology*
Nitric Oxide / toxicity*
Nitric Oxide Synthase / biosynthesis,  physiology
Reg. No./Substance:
0/Free Radicals; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 10102-43-9/Nitric Oxide; EC Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F,...
Next Document:  Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression throu...