| Nitric oxide exhalation correlates with ventilatory response to exercise in patients with heart disease. | |
| | |
MedLine Citation:
|
PMID: 14607203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: It is controversial whether or not pulmonary nitric oxide (NO) production, reflected in the end-tidal alveolar NO concentration, is diminished in patients with heart failure. Since pulmonary perfusion is regulated by NO production, decreased NO production in the pulmonary vasculature is assumed to result in diminished lung perfusion and further increases in ventilation-perfusion mismatch. The aim of this study is to investigate whether exhaled NO correlates with both exercise-induced hyperpnea and exercise tolerance in patients with heart disease. METHODS AND RESULTS: Forty-two patients with heart disease were enrolled (history of prior myocardial infarction (n=19), dilated cardiomyopathy (n=2), hypertensive heart disease (n=5) and prior open-heart surgery (n=16)). During cardiopulmonary exercise testing, exhaled air was collected and end-tidal NO (ETNO) was measured using a chemiluminescent method. Peak ETNO was found to correlate positively with both ventilatory anaerobic threshold (r=0.468) and peak VO(2) (r=0.562). The VE-CO(2) slope, which reflects the ventilatory response to exercise, correlated negatively with peak ETNO (r=-0.588). CONCLUSION: These data indicate that NO exhalation correlates, inversely, with the ventilatory response to exercise and directly with exercise intolerance, although the weakness of the correlation coefficient suggests there may be other possible mechanisms. |
| | |
Authors:
|
Hitoshi Adachi; Shigeru Oshima; Shigeki Sakurai; Takuji Toyama; Hiroshi Hoshizaki; Koichi Taniguchi; Haruki Ito |
Related Documents
:
|
2209023 - Dynamic pulmonary arterial hypertension: a new form of pulmonary hypertension in patien... 3589593 - Cardiorespiratory function after correction of tetralogy of fallot. modifying effect of... 7900783 - Effect of endurance training on hepatic glycogenolysis and gluconeogenesis during prolo... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: European journal of heart failure Volume: 5 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2003 Oct |
Date Detail:
|
Created Date: 2003-11-10 Completed Date: 2004-03-12 Revised Date: 2011-06-08 |
Medline Journal Info:
|
Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 639-43 Citation Subset: IM |
Affiliation:
|
Gunma Prefectural Cardiovascular Center, 3-12 Kameizumi, Maebashi, Gunma 371-0004, Japan. h-adachi@ops.dti.ne.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chemiluminescent Measurements Exercise* Exercise Test Exercise Tolerance Exhalation / physiology* Female Heart Diseases / physiopathology* Humans Male Middle Aged Nitric Oxide / analysis*, biosynthesis Pulmonary Ventilation / physiology* |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhanced levels of CD154 (CD40 ligand) on platelets in patients with chronic heart failure.
Next Document: Reversible pulmonary hypertension in heart transplant candidates--pretransplant evaluation and outco...