Document Detail

Nitric oxide exhalation correlates with ventilatory response to exercise in patients with heart disease.
MedLine Citation:
PMID:  14607203     Owner:  NLM     Status:  MEDLINE    
AIMS: It is controversial whether or not pulmonary nitric oxide (NO) production, reflected in the end-tidal alveolar NO concentration, is diminished in patients with heart failure. Since pulmonary perfusion is regulated by NO production, decreased NO production in the pulmonary vasculature is assumed to result in diminished lung perfusion and further increases in ventilation-perfusion mismatch. The aim of this study is to investigate whether exhaled NO correlates with both exercise-induced hyperpnea and exercise tolerance in patients with heart disease.
METHODS AND RESULTS: Forty-two patients with heart disease were enrolled (history of prior myocardial infarction (n=19), dilated cardiomyopathy (n=2), hypertensive heart disease (n=5) and prior open-heart surgery (n=16)). During cardiopulmonary exercise testing, exhaled air was collected and end-tidal NO (ETNO) was measured using a chemiluminescent method. Peak ETNO was found to correlate positively with both ventilatory anaerobic threshold (r=0.468) and peak VO(2) (r=0.562). The VE-CO(2) slope, which reflects the ventilatory response to exercise, correlated negatively with peak ETNO (r=-0.588).
CONCLUSION: These data indicate that NO exhalation correlates, inversely, with the ventilatory response to exercise and directly with exercise intolerance, although the weakness of the correlation coefficient suggests there may be other possible mechanisms.
Hitoshi Adachi; Shigeru Oshima; Shigeki Sakurai; Takuji Toyama; Hiroshi Hoshizaki; Koichi Taniguchi; Haruki Ito
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of heart failure     Volume:  5     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-10     Completed Date:  2004-03-12     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  639-43     Citation Subset:  IM    
Gunma Prefectural Cardiovascular Center, 3-12 Kameizumi, Maebashi, Gunma 371-0004, Japan.
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MeSH Terms
Chemiluminescent Measurements
Exercise Test
Exercise Tolerance
Exhalation / physiology*
Heart Diseases / physiopathology*
Middle Aged
Nitric Oxide / analysis*,  biosynthesis
Pulmonary Ventilation / physiology*
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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