| Nitric oxide-endothelin-1 interaction in humans. | |
| | |
MedLine Citation:
|
PMID: 9134909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Healthy men received NG-monomethyl-L-arginine (L-NMMA) intravenously to study cardiovascular and metabolic effects of nitric oxide synthase blockade and whether this alters the response to endothelin-1 (ET-1) infusion. Controls only received ET-1. L-NMMA effects were that heart rate (17%) cardiac output (17%), and splanchnic and renal blood flow (both 33%) fell promptly (all P < 0.01). Mean arterial blood pressure (6%), and systemic (28%) and pulmonary (40%) vascular resistance increased (P < 0.05 to 0.001). Arterial ET-1 levels (21%) increased due to a pulmonary net ET-1 release (P < 0.05 to 0.01). Splanchnic glucose output (SGO) fell (26%, P < 0.01). Arterial insulin and glucagon were unchanged. Subsequent ET-1 infusion caused no change in mean arterial pressure, heart rate, or cardiac output, as found in the present controls, or in splanchnic and renal blood flow or splanchnic glucose output as previously found with ET-1 (G. Ahlborg, E. Weitzberg, and J. M. Lundberg. J. Appl. Physiol. 79: 141-145, 1995). In conclusion, L-NMMA like ET-1, induces prolonged cardiovascular effects and suppresses SGO. L-NMMA causes pulmonary ET-1 release and blocks responses to ET-1 infusion. The results indicate that nitric oxide inhibits ET-1 production and thereby interacts with ET-1 regarding increase in vascular tone and reduction of SGO in humans. |
| | |
Authors:
|
G Ahlborg; J M Lundberg |
Related Documents
:
|
18501719 - Dietary nitrite restores no homeostasis and is cardioprotective in endothelial nitric o... 10051079 - Nitric oxide production is enhanced in patients with heat stroke. 3177669 - Endothelium-dependent pressure-induced contraction of isolated canine carotid arteries. 12569269 - Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitr... 10805399 - Role of endothelium and nitric oxide in experimental hypertension. 9486319 - Long-term measurement of arterial blood pressure in conscious mice. 1676339 - Direct effects in vivo of angiotensins i and ii on the canine sinus node. 17629529 - Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits. 16114519 - Application of surface plasmon resonance sensing to studying elastohydrodynamic lubrica... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 82 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1997 May |
Date Detail:
|
Created Date: 1997-07-21 Completed Date: 1997-07-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1593-600 Citation Subset: IM |
Affiliation:
|
Department of Clinical Physiology, Huddinge University Hospital, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Gas Analysis Blood Glucose Blood Pressure / drug effects Cardiac Output / drug effects Endothelin-1 / blood* Enzyme Inhibitors / administration & dosage Glucagon / blood Heart Rate / drug effects Humans Injections, Intravenous Insulin / blood Male Muscle Contraction / physiology Muscle, Smooth / drug effects, enzymology Nitric Oxide / biosynthesis, metabolism* Nitric Oxide Synthase / antagonists & inhibitors Pulmonary Circulation / drug effects, physiology Renal Circulation / drug effects, physiology Respiration / physiology Splanchnic Circulation / drug effects, physiology Vascular Resistance / drug effects omega-N-Methylarginine / administration & dosage |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Endothelin-1; 0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 11061-68-0/Insulin; 17035-90-4/omega-N-Methylarginine; 9007-92-5/Glucagon; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Very high pressures are required to cause stress failure of pulmonary capillaries in thoroughbred ra...
Next Document: Effects of supplemental oxygen on forearm vasodilation in humans.