Document Detail

Nitric oxide-endothelin-1 interaction in humans.
MedLine Citation:
PMID:  9134909     Owner:  NLM     Status:  MEDLINE    
Healthy men received NG-monomethyl-L-arginine (L-NMMA) intravenously to study cardiovascular and metabolic effects of nitric oxide synthase blockade and whether this alters the response to endothelin-1 (ET-1) infusion. Controls only received ET-1. L-NMMA effects were that heart rate (17%) cardiac output (17%), and splanchnic and renal blood flow (both 33%) fell promptly (all P < 0.01). Mean arterial blood pressure (6%), and systemic (28%) and pulmonary (40%) vascular resistance increased (P < 0.05 to 0.001). Arterial ET-1 levels (21%) increased due to a pulmonary net ET-1 release (P < 0.05 to 0.01). Splanchnic glucose output (SGO) fell (26%, P < 0.01). Arterial insulin and glucagon were unchanged. Subsequent ET-1 infusion caused no change in mean arterial pressure, heart rate, or cardiac output, as found in the present controls, or in splanchnic and renal blood flow or splanchnic glucose output as previously found with ET-1 (G. Ahlborg, E. Weitzberg, and J. M. Lundberg. J. Appl. Physiol. 79: 141-145, 1995). In conclusion, L-NMMA like ET-1, induces prolonged cardiovascular effects and suppresses SGO. L-NMMA causes pulmonary ET-1 release and blocks responses to ET-1 infusion. The results indicate that nitric oxide inhibits ET-1 production and thereby interacts with ET-1 regarding increase in vascular tone and reduction of SGO in humans.
G Ahlborg; J M Lundberg
Related Documents :
12470199 - Cardiovascular system of offsprings of hypertensive rats with defective nitric oxide pr...
17824809 - Comparison of the effect of simvastatin, spironolactone and l-arginine on endothelial f...
8736429 - Involvement of nitric oxide in the smooth muscle tone of the isolated canine spleen and...
10051079 - Nitric oxide production is enhanced in patients with heat stroke.
18927469 - Interaction between p450 eicosanoids and nitric oxide in the control of arterial tone i...
23572219 - Radiofrequency-induced small bowel thermofusion: an ex vivo study of intestinal seal ad...
7581469 - New method to quantify the urodynamic improvement when treating bladder outlet obstruct...
6380939 - High-frequency ventilation compared to conventional positive-pressure ventilation in th...
8143709 - Basic mechanisms and clinical consequences of cyclic changes in pulmonary blood flow an...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  82     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-21     Completed Date:  1997-07-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1593-600     Citation Subset:  IM    
Department of Clinical Physiology, Huddinge University Hospital, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Gas Analysis
Blood Glucose
Blood Pressure / drug effects
Cardiac Output / drug effects
Endothelin-1 / blood*
Enzyme Inhibitors / administration & dosage
Glucagon / blood
Heart Rate / drug effects
Injections, Intravenous
Insulin / blood
Muscle Contraction / physiology
Muscle, Smooth / drug effects,  enzymology
Nitric Oxide / biosynthesis,  metabolism*
Nitric Oxide Synthase / antagonists & inhibitors
Pulmonary Circulation / drug effects,  physiology
Renal Circulation / drug effects,  physiology
Respiration / physiology
Splanchnic Circulation / drug effects,  physiology
Vascular Resistance / drug effects
omega-N-Methylarginine / administration & dosage
Reg. No./Substance:
0/Blood Glucose; 0/Endothelin-1; 0/Enzyme Inhibitors; 0/Insulin; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 9007-92-5/Glucagon; EC Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Very high pressures are required to cause stress failure of pulmonary capillaries in thoroughbred ra...
Next Document:  Effects of supplemental oxygen on forearm vasodilation in humans.