| Nitric oxide donors induce ripening of the human uterine cervix: a randomised controlled trial. | |
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MedLine Citation:
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PMID: 9307534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether nitric oxide donors can induce cervical ripening before surgical termination of pregnancy in the first trimester. DESIGN: Prospective, randomised controlled trial. SETTING: Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow. PARTICIPANTS: Forty-eight primigravid women undergoing surgical termination of pregnancy before 12 weeks of gestation. METHODS: The women were randomised to receive per vaginam before surgery either the nitric oxide donor isosorbide mononitrate, the nitric oxide donor glyceryl trinitrate, the prostaglandin analogue gemeprost, or no treatment. MAIN OUTCOME MEASURES: The cumulative force required to dilate the cervix to 8 mm was measured objectively and the cervical diameter before surgical dilatation was recorded. RESULTS: Following isosorbide mononitrate or gemeprost, a lower cumulative force was required to dilate the cervix to 8 mm and a higher cervical diameter before dilatation was recorded. Pretreatment with glyceryl trinitrate reduced the cumulative force required to dilate the cervix but had no effect on cervical diameter. CONCLUSIONS: Like the prostaglandin analogue gemeprost, the nitric oxide donors isosorbide mononitrate and glyceryl trinitrate can effect cervical ripening. Nitric oxide donors may provide an alternative to prostaglandins for cervical ripening before surgical procedures in the first trimester. |
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Authors:
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A J Thomson; C B Lunan; A D Cameron; I T Cameron; I A Greer; J E Norman |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of obstetrics and gynaecology Volume: 104 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-10-23 Completed Date: 1997-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1054-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Glasgow. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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therapeutic use* Abortion, Induced / methods* Administration, Intravaginal Adult Alprostadil / analogs & derivatives Cervix Uteri / drug effects* Female Humans Isosorbide Dinitrate / analogs & derivatives, therapeutic use Nitric Oxide / therapeutic use* Pregnancy Pregnancy Trimester, First Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 10102-43-9/Nitric Oxide; 16051-77-7/isosorbide-5-mononitrate; 64318-79-2/gemeprost; 745-65-3/Alprostadil; 87-33-2/Isosorbide Dinitrate |
| Comments/Corrections | |
Comment In:
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Br J Obstet Gynaecol. 1997 Dec;104(12):1422
[PMID:
9422031
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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