Document Detail

Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury.
MedLine Citation:
PMID:  23164361     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neointimal hyperplasia limits the longevity of vascular interventions. Nitric oxide (NO) is well known to inhibit neointimal hyperplasia. However, delivery of NO to the vasculature is challenging. Our study aims to evaluate the efficacy of delivering NO to the site of injury using a permeable balloon catheter. Our hypothesis is that ultra-short duration NO delivery using a permeable balloon catheter will inhibit neointimal hyperplasia.
MATERIALS AND METHODS: Ten-week-old male Sprague-Dawley rats underwent carotid artery balloon injury. Groups included: (1) control, (2) injury, (3) injury + periadventitial NO, and (4) injury + endoluminal NO via permeable balloon catheter. The catheter was inflated to 5 atm pressure for 5 min. Arteries were harvested 2 wk following injury. Morphometric assessment for neointimal hyperplasia and immunohistochemical staining for inflammatory markers were performed.
RESULTS: Injury increased neointimal hyperplasia compared with control (intima/media area [I/M] ratio 1.07 versus 0.11, respectively, P < 0.001). Periadventitial delivery of NO reduced the I/M area ratio compared with injury alone (55% decrease, P < 0.001). Endoluminal delivery of NO also reduced the I/M area ratio compared with injury alone (65% decrease; P < 0.001). Both endoluminal and periadventitial NO affected the I/M ratio by reducing the intimal area (64% and 46%, respectively, P < 0.001) whereas neither affected the medial area. Periadventitial NO delivery increased lumen area (P < 0.05), whereas endoluminal NO delivery increased circumference (P < 0.05). Periadventitial NO delivery inhibited macrophage intimal infiltration compared with injury alone (P < 0.05).
CONCLUSIONS: These data demonstrate that short-duration endoluminal NO delivery via permeable balloon catheters inhibits neointimal hyperplasia following arterial interventions. Endoluminal delivery of NO could become a focus for future clinical interventions.
George E Havelka; Edward S Moreira; Monica P Rodriguez; Nick D Tsihlis; Zheng Wang; Janet Martínez; Joseph A Hrabie; Larry K Kiefer; Melina R Kibbe
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-10
Journal Detail:
Title:  The Journal of surgical research     Volume:  180     ISSN:  1095-8673     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-04-11     Revised Date:  2014-05-23    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Angioplasty, Balloon
Carotid Artery Injuries / drug therapy*,  pathology
Neointima / pathology*
Nitric Oxide / administration & dosage*
Rats, Sprague-Dawley
Grant Support
P30 CA060553/CA/NCI NIH HHS; T32 HL094293/HL/NHLBI NIH HHS; T32 HL094293-01/HL/NHLBI NIH HHS
Reg. No./Substance:
31C4KY9ESH/Nitric Oxide

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