Document Detail


Nitric oxide concentrations in gas emanating from the tails of obese rats.
MedLine Citation:
PMID:  24112958     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study was undertaken to investigate the effects of oral L-arginine administration and exercising training on the NO concentration emanating from rat tail and NOx in plasma. Obese (fa/fa) Zucker rats (n = 22) were divided into four groups: (1) oral L-arginine administration (A) (n = 6), (2) exercise training (E), (3) exercise training + L-arginine administration (E + A) (n = 5), and (4) non-exercise training + non-L-arginine administration (N) (n = 6). The control (+/+) Zucker rats (n = 22) were also divided into the same four groups. The body weight of the E + A and the A groups was significantly lower than that of the N group. The NO concentration emitted from the tail was higher in the L-arginine (E + A and A) groups than in the non-L-arginine (E and N) groups in both obese and control rats. Exercise training did not affect the skin gas NO concentration in either obese or control rats. Plasma NOx concentrations in four obese rats were significantly higher than those observed in control rats. Exercise training did not influence the level of plasma NOx in obese or control rats. In conclusion, this study confirmed that L-arginine administration increases the skin gas NO concentration and obesity increases the plasma NOx level. The plasma NOx concentrations were not affected by L-arginine administration or exercise training in obese or control rats.
Authors:
Rin Nakanishi; Jun Ohwaki; Shunsuke Emoto; Toshiki Mori; Kosuke Mizuno; Takao Tsuda; Hiroshi Itoh; Tetsuo Ohkuwa
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Redox report : communications in free radical research     Volume:  18     ISSN:  1743-2928     ISO Abbreviation:  Redox Rep.     Publication Date:  2013  
Date Detail:
Created Date:  2013-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9511366     Medline TA:  Redox Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  233-237     Citation Subset:  -    
Affiliation:
Nagoya Institute of Technology, Nagoya, Japan.
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