| Nitric oxide is a central mediator of penile erection. | |
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MedLine Citation:
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PMID: 7870289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to evaluate a possible role of brain nitric oxide (NO) on the control of penile erection, the effect of nitroglycerin, that is thought to act by producing NO, was studied on spontaneous penile erection in male rats. In addition the effect of drugs that prevent NO formation and/or activity such as NG-nitro-L-arginine methyl ester (NAME) and methylene blue, on N-methyl-D-aspartic acid (NMDA)-, apomorphine- and oxytocin-induced penile erection was also studied. Nitroglycerin induced penile erection in a dose-dependent manner when given intracerebroventricularly (i.c.v.) (33-99 micrograms) or in the paraventricular nucleus of the hypothalamus (0.8-3.3 micrograms). Nitroglycerin-induced penile erection was prevented by the guanylate cyclase inhibitor methylene blue injected i.c.v. (200-400 micrograms) but not in the paraventricular nucleus of the hypothalamus (10-20 micrograms). Conversely, NMDA-, apomorphine- and oxytocin-induced penile erection was prevented by NAME (150 micrograms) or methylene blue (400 micrograms) given i.c.v. NAME (20 micrograms), but not methylene blue (20 micrograms), was effective in preventing the behavioral response also when injected in the paraventricular nucleus. The present results suggest that NO is a common mediator of several neurotransmitters involved in the control of this primary male sexual function. |
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Authors:
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A Argiolas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuropharmacology Volume: 33 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1995-03-28 Completed Date: 1995-03-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1339-44 Citation Subset: IM |
Affiliation:
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Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / pharmacology Arginine / analogs & derivatives Dose-Response Relationship, Drug Injections Injections, Intraventricular Male Methylene Blue / pharmacology N-Methylaspartate / pharmacology NG-Nitroarginine Methyl Ester Nitric Oxide / antagonists & inhibitors, physiology* Nitroglycerin / pharmacology* Oxytocin / pharmacology Paraventricular Hypothalamic Nucleus / anatomy & histology Penile Erection / drug effects, physiology* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 50-56-6/Oxytocin; 50903-99-6/NG-Nitroarginine Methyl Ester; 55-63-0/Nitroglycerin; 58-00-4/Apomorphine; 61-73-4/Methylene Blue; 6384-92-5/N-Methylaspartate; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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