| Nitric oxide biomarkers increase during exercise-induced vasodilation in the forearm. | |
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MedLine Citation:
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PMID: 10727066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the study was to determine if exercise-induced vasodilation was associated with an increase in forearm plasma levels of nitric oxide (NO) biomarkers (NO2- + NO3- and L-citrulline). Twelve healthy subjects (27+/-6 yrs) performed incremental rhythmic forearm exercise with the nondominant hand for 6 min each at 15, 30 and 45% of maximal voluntary contraction (MVC). Forearm blood flow (FBF) was determined in the exercise arm using venous occlusion plethysmography. Blood samples were obtained from the antecubital vein of the exercise and nonexercise arms for the measurement of NO biomarkers. In the exercise arm, FBF increased by a mean of 150%, 335% and 585% above baseline at 15, 30 and 45% of MVC, respectively. (ANOVA, P= 0.0001). Venous plasma NO2- + NO3- levels increased from 24+/-4 micromol/L at baseline, to 29+/-5, 32+/-4 and 3+/-4 micromol/L (ANOVA, P = 0.0001). Venous plasma L-citrulline levels increased from 31+/-5 micromol/L at baseline to 58+/-10, 87+/-7 and 141+/-15 micromol/L (ANOVA, P = 0.0001). There was a linear relationship between FBF and venous plasma NO2- + NO3- (slope= 0.38+/-0.10, P=0.0007) and between L-citrulline, (slope= 5.1 +/-1.3, P = 0.0004). Venous plasma levels of NO2- + NO3- and L-citrulline in the nonexercise arm were unchanged. These results demonstrate that exercise-induced vasodilation in the forearm is associated with forearm plasma levels of NO2- + NO3- and L-citrulline, in vivo markers of NO production. |
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Authors:
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M D Brown; M Srinivasan; R V Hogikyan; D R Dengel; S G Glickman; A Galecki; M A Supiano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of sports medicine Volume: 21 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-04-21 Completed Date: 2000-04-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 83-9 Citation Subset: IM; S |
Affiliation:
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Department of Internal Medicine, University of Michigan, Ann Arbor, USA. mb166@umail.umd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis Exercise / physiology* Female Forearm Humans Male Muscle, Skeletal / physiology Nitric Oxide / blood* Sensitivity and Specificity Vasodilation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AG08808/AG/NIA NIH HHS; KO 1 AG0072301/AG/NIA NIH HHS; T32 AG00114/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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