| Nitric oxide as a mediator of reduced arterial responsiveness in septic patients. | |
| | |
MedLine Citation:
|
PMID: 8681578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the functional status of arteries in patients with septic shock, each of whom suffered from severe hypotension. DESIGN: Experimental, comparative study. SETTING: Laboratory in a university hospital. SUBJECTS: Mesenteric artery resected from omentum was obtained from patients (n = 3) with or without (n = 4) sepsis. INTERVENTIONS: To study the effect of modification of the nitric oxide system in human arteries during sepsis, changes in norepinephrine-evoked isometric tension in mesenteric arterial rings were measured. MEASUREMENTS AND MAIN RESULTS: Mesenteric arteries were isolated from omentum resected from three patients with septic shock and from four patients with no inflammatory conditions; in each case, during an intestinal anastomosis. In arterial rings, after a 1-hr equilibration with Krebs solution, changes in isometric tension evoked by norepinephrine were measured for 5 mins every 20 mins. The tension initially evoked in rings from septic patients was lower than in those rings from nonseptic patients and, unlike the controls, it decreased with a short time course. The addition of 300 micromol/L of N(G)-nitro-L-arginine methyl ester or 10 micromol of N(G)-nitro-L-arginine methyl ester or 10 micromol/L of methylene blue reversed this decrease. CONCLUSION: These results indicate that in patients with septic shock, the main cause of reduced sensitivity to pressor agents may be a massive generation of nitric oxide via the L-arginine pathway. |
| | |
Authors:
|
I Tsuneyoshi; Y Kanmura; N Yoshimura |
Related Documents
:
|
7932318 - The views of elderly patients and their relatives on cardiopulmonary resuscitation. 19875238 - Vancomycin pharmacokinetics in patients with severe burn injuries. 8424288 - Preoxygenation techniques: the value of nitrous oxide. 8150838 - The hemostatic effect of fibrin glue on graft donor sites. 10988128 - Detection of obliterative bronchiolitis after lung transplantation by indexes of ventil... 2259838 - Early rheumatoid arthritis--onset, course, and outcome over 2 years. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Critical care medicine Volume: 24 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1996 Jun |
Date Detail:
|
Created Date: 1996-08-21 Completed Date: 1996-08-21 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1083-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Arginine / analogs & derivatives, pharmacology Enzyme Inhibitors / pharmacology Female Hemodynamics Humans Hypotension / complications, etiology Mesenteric Arteries / drug effects* Middle Aged NG-Nitroarginine Methyl Ester Nitric Oxide / biosynthesis* Norepinephrine / pharmacology* Shock, Septic / complications, etiology, physiopathology* Vasoconstriction / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-41-2/Norepinephrine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Research curricula in critical care fellowships--a survey.
Next Document: Effect of hypoxia on lung, heart, and liver insulin-like growth factor-I gene and receptor expressio...