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Nitric oxide and antioxidant enzymes in venous and cord blood of late preterm and term omani mothers.
MedLine Citation:
PMID:  22912922     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study assessed the role of oxidative stress in parturition in Omani mothers following growing reports that late preterm neonates were at greater risk than term neonates of perinatal death.
METHODS: Venous blood samples were collected during labour, and cord (neonatal) blood samples were taken after childbirth in late preterm and term from women at Sultan Qaboos University Hospital, Oman. Plasma nitric oxide (NO) concentrations, erythrocyte catalase (CAT). Erythrocyte glutathione peroxidase (GPx) activities were measured using spectrophotometric methods.
RESULTS: When compared with term mothers, late preterm mothers had markedly higher NO concentrations (μmol/L) 17.1 ± 3.3 versus 11.0 ± 5.5 (P <0.0001), and lower GPx values (U/g Hb) 94.1 ± 12.9 versus 110.4 ± 12.3 (P <0.0001). Late preterm mothers were significantly younger (P = 0.027) than term mothers and had neonates that weighed significantly less (P <0.0001) than term neonates. GPx activity was significantly reduced (P = 0.001) in late preterm neonates as compared to term neonates. CAT showed no change in activity in any comparison.
CONCLUSION: Distinctly higher values of NO and lower GPx activity were found in late preterm mothers relative to term mothers; also, lower GPx in late preterm neonates relative to term neonates suggested a pro-oxidant-antioxidant imbalance due to the greater oxidative burden in late preterm parturition.
Authors:
Clifford Abiaka; Lovina Machado
Publication Detail:
Type:  Journal Article     Date:  2012-07-15
Journal Detail:
Title:  Sultan Qaboos University medical journal     Volume:  12     ISSN:  2075-0528     ISO Abbreviation:  Sultan Qaboos Univ Med J     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-22     Completed Date:  2012-10-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101519915     Medline TA:  Sultan Qaboos Univ Med J     Country:  Oman    
Other Details:
Languages:  eng     Pagination:  300-5     Citation Subset:  -    
Affiliation:
Department of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman;
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