| Nitric oxide and angiotensin II regulate cardiovascular homeostasis and the arterial baroreflex control of heart rate in conscious lambs. | |
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MedLine Citation:
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PMID: 21987534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the potential role of angiotensin II (Ang II) type 1 receptors (AT(1)Rs) as well as endogenously produced nitric oxide (NO) in regulating cardiovascular homeostasis during ontogeny, experiments were carried out in conscious lambs aged approximately 1 week (N = 9) and 6 weeks (N = 11). The arterial baroreflex control of heart rate (HR) was assessed before and after intravenous (IV) infusion of the selective AT(1)R antagonist, ZD 7155, before and after IV administration of the L-arginine analogue, N(G)-nitro-L-arginine methyl ester (L-NAME). In both groups, after ZD 7155 alone, mean arterial pressure decreased then increased after L-NAME. At 1 but not 6 weeks, HR decreased after ZD 7155 as well as after L-NAME. At 1 but not 6 weeks, there was a decrease in the HR range after ZD 7155 and after ZD 7155 + L-NAME, as compared to control. There was also a decrease in minimum HR after ZD 7155 + L-NAME at 1 week. These data provide new evidence that, together, Ang II and NO regulate cardiovascular homeostasis as well as the arterial baroreflex of HR early in life which may help to explain the activation of these two systems early in life. |
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Authors:
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Stephanie J Wehlage; Francine G Smith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-10-10 |
Journal Detail:
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Title: Journal of the renin-angiotensin-aldosterone system : JRAAS Volume: 13 ISSN: 1752-8976 ISO Abbreviation: J Renin Angiotensin Aldosterone Syst Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-05 Completed Date: 2012-06-27 Revised Date: 2013-05-03 |
Medline Journal Info:
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Nlm Unique ID: 100971636 Medline TA: J Renin Angiotensin Aldosterone Syst Country: England |
Other Details:
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Languages: eng Pagination: 99-106 Citation Subset: IM |
Affiliation:
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Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology* Animals Arteries / drug effects, physiology* Baroreflex / drug effects* Consciousness / drug effects* Female Heart Rate / drug effects* Homeostasis / drug effects* Kidney / blood supply, drug effects Male NG-Nitroarginine Methyl Ester / pharmacology Naphthyridines / pharmacology Nitric Oxide / pharmacology* Regional Blood Flow / drug effects Sheep, Domestic / physiology Vascular Resistance / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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14082-1//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Naphthyridines; 0/ZD 7155; 10102-43-9/Nitric Oxide; 11128-99-7/Angiotensin II; 50903-99-6/NG-Nitroarginine Methyl Ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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