Document Detail

Nitric oxide alone is an insufficient biomarker of exposure to microbes in a moisture-damaged building.
MedLine Citation:
PMID:  12454791     Owner:  NLM     Status:  MEDLINE    
Several epidemiological studies have revealed a large variety of adverse health effects related to exposure to microbes in moisture damaged buildings. Recently some evidence has been reported for a biochemical linkage between microbial exposure and the respiratory symptoms suffered by the occupants. The objective of the current study was to evaluate the value of nitric oxide (NO) measurements in determining the inflammatory status of airways in inhabitants of problem buildings. NO was measured by a chemiluminescence analyzer from the exhaled air. In addition, NO was determined as its metabolite nitrite from nasal lavage (NL) and induced sputum (IS) samples and also via the expression of inducible nitric oxide synthase (iNOS) in the cells. Occupants of moisture-damaged and reference schools were studied. The sampling was performed at the end of the spring term, at the end of the summer vacation, during the winter term, and after a 1-wk winter holiday. No statistically significant differences in NO levels were detected between the studied groups or between exposure and vacation periods. iNOS was not detected from IS or NL samples of the exposed occupants. These results suggest that NO measurements alone are not sufficient to quantify airway inflammation when evaluating subjects exposed to microbes present in moisture-damaged buildings.
M Purokivi; M-R Hirvonen; J Randell; M Roponen; H Tukiainen
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Inhalation toxicology     Volume:  14     ISSN:  0895-8378     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-27     Completed Date:  2003-06-06     Revised Date:  2011-10-27    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1279-90     Citation Subset:  IM    
Department of Respiratory Medicine, Kuopio University Hospital, PO Box 1777, FIN-70211 Kuopio, Finland.
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MeSH Terms
Air Pollution, Indoor / adverse effects
Biological Markers
Chemiluminescent Measurements
Fungi / pathogenicity*
Inflammation / diagnosis,  microbiology
Nasal Lavage Fluid / chemistry
Nitric Oxide / analysis*,  biosynthesis
Nitric Oxide Synthase / metabolism
Nitric Oxide Synthase Type II
Occupational Exposure / adverse effects*
Respiratory Tract Diseases / diagnosis,  microbiology
Skin Tests
Sputum / chemistry
Reg. No./Substance:
0/Biological Markers; 10102-43-9/Nitric Oxide; 7732-18-5/Water; EC protein, human; EC Oxide Synthase; EC Oxide Synthase Type II

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