| Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages. | |
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MedLine Citation:
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PMID: 21466852 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Peroxiredoxins (Prxs) are a family of peroxidases that maintain thiol homeostasis by catalyzing the reduction of organic hydroperoxides, H(2)O(2) and peroxynitrite. Under conditions of oxidative stress, eukaryotic Prxs can be inactivated by the substrate-dependent oxidation of the catalytic cysteine to sulfinic acid, which may regulate the intracellular messenger function of H(2)O(2). A small redox protein, sulfiredoxin (Srx), only conserved in eukaryotes, has been shown to reduce sulfinylated 2-Cys-Prxs, adding to the complexity of the H(2)O(2) signaling network. In the present study, we addressed the regulation of Srx expression in immunostimulated primary macrophages that produce both reactive oxygen species (ROS) and nitric oxide (NO(.)). We present genetic evidence that NO-mediated Srx up-regulation is mediated by the transcription factor nuclear factor erythroid 2-related factor (Nrf2). We also show that the NO(.)/Srx pathway inhibits generation of ROS. These results reveal a link between innate immunity and H(2)O(2) signaling. We propose that an NO(.)/Nrf2/Srx pathway participates in the maintenance of redox homeostasis in cytokine-activated macrophages and other inflammatory settings. |
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Authors:
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Kahina Abbas; Jacques Breton; Anne-Gaelle Planson; Cécile Bouton; Jérome Bignon; Cendrine Seguin; Sylvie Riquier; Michel B Toledano; Jean-Claude Drapier |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-2 |
Journal Detail:
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Title: Free radical biology & medicine Volume: - ISSN: 1873-4596 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010. Published by Elsevier Inc. |
Affiliation:
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Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Centre de Recherche de Gif, 91190 Gif-sur-Yvette, France. |
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