| Nitric acid passivation does not affect in vitro biocompatibility of titanium. | |
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MedLine Citation:
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PMID: 14696657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: In general, both chemical composition and surface features of implants affect cell response. The aim of this study was to evaluate the effect of titanium (Ti) passivation on the response of rat bone marrow cells, considering cell attachment, cell morphology, cell proliferation, total protein content, alkaline phosphatase (ALP) activity, and bonelike nodule formation. MATERIALS AND METHODS: Cells were cultured on both commercially pure titanium (cpTi) and titanium-aluminium-vanadium alloy (Ti-6Al-4V) discs, either passivated or not. For attachment evaluation, cells were cultured for 4 and 24 hours. Cell morphology was evaluated after 4 days. After 7, 14, and 21 days, cell proliferation, total protein content, and ALP activity were evaluated. Bonelike nodule formation was evaluated after 21 days. Data were compared by analysis of variance and the Duncan multiple range test. RESULTS: Cell attachment, cell morphology, cell proliferation, total protein content, ALP activity, and bonelike nodule formation all were unaffected by Ti composition or passivation. DISCUSSION AND CONCLUSION: Although the protocol for passivation used here could interfere with the pattern of ions released from Ti-6Al-4V and cpTi surfaces, the present study did not show any effect of this surface treatment on in vitro biocompatibility of Ti as evaluated by osteoblast attachment, proliferation, and differentiation. |
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Authors:
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Adriana C L Faria; Márcio M Beloti; Adalberto L Rosa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of oral & maxillofacial implants Volume: 18 ISSN: 0882-2786 ISO Abbreviation: Int J Oral Maxillofac Implants Publication Date: 2003 Nov-Dec |
Date Detail:
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Created Date: 2003-12-30 Completed Date: 2004-02-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8611905 Medline TA: Int J Oral Maxillofac Implants Country: United States |
Other Details:
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Languages: eng Pagination: 820-5 Citation Subset: D; IM |
Affiliation:
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Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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analysis Analysis of Variance Animals Biocompatible Materials / chemistry* Bone Marrow Cells / physiology Cell Adhesion Cell Culture Techniques Cell Division Cell Size Dental Alloys / chemistry Male Nitric Acid / chemistry* Osteoblasts / physiology Osteogenesis / physiology Proteins / analysis Rats Rats, Wistar Surface Properties Time Factors Titanium / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Dental Alloys; 0/Proteins; 12743-70-3/titanium alloy (TiAl6V4); 7440-32-6/Titanium; 7697-37-2/Nitric Acid; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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