Document Detail


Nitric oxide formation versus scavenging: the red blood cell balancing act.
MedLine Citation:
PMID:  22687616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitric oxide (NO) is a key modulator of vascular homeostasis controlling critical functions related to blood flow, respiration, cell death and proliferation, and protecting the vasculature from pro-inflammatory and coagulative stresses. Inhibition of NO formation, and/or diversion of NO away from its physiological signalling targets lead to dysregulated NO bioavailability, a hallmark of numerous vascular and pulmonary diseases. Current concepts suggest that the balance between NO formation and NO scavenging is critical in disease development, with the corollary being that redressing the balance offers a target for therapeutic intervention. Evidence presented over the last two decades has seen red blood cells (RBCs) and haemoglobin specifically emerge as prominent effectors in this paradigm. In this symposium review article, we discuss recent insights into the mechanisms by which RBCs may modulate the balance between NO-formation and inhibition. We discuss how these mechanisms may become dysfunctional to cause disease, highlight key questions that remain, and discuss the potential impact of these insights on therapeutic opportunities.
Authors:
Benjamin Y Owusu; Ryan Stapley; Rakesh P Patel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-06-11
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-19     Completed Date:  2013-06-18     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  4993-5000     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Alabama at Birmingham, 901 19th Street South, BMRII 532, Birmingham, AL 35294, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Erythrocytes / metabolism*
Hemoglobins / metabolism
Humans
Nitric Oxide / metabolism*
Nitrites / metabolism
Grant Support
ID/Acronym/Agency:
HL092624/HL/NHLBI NIH HHS; HL095468/HL/NHLBI NIH HHS; R01 HL092624/HL/NHLBI NIH HHS; R01 HL095468/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Nitrites; 10102-43-9/Nitric Oxide
Comments/Corrections

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