Document Detail

Nitric oxide modulation of low-frequency oscillations in cortical vessels in FHM--a NIRS study.
MedLine Citation:
PMID:  22352839     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The pathophysiological alterations in patients with familial hemiplegic migraine (FHM) are not yet fully known. The headache characteristics in patients with FHM mutations have been examined in a series of glyceryl trinitrate (GTN) provocation studies in FHM patients, but the cortical vascular response to GTN in FHM patients has never been investigated before.
OBJECTIVE: To investigate changes in spontaneous low-frequency oscillations (LFO) of cortical vessels in response to the nitric oxide donor GTN by near-infrared spectroscopy in FHM patients.
METHODS: Twenty-three FHM patients without known mutations and 9 healthy controls received a continuous intravenous infusion of GTN 0.5 µg/kg/minute over 20 minutes. Using near-infrared spectroscopy, we recorded oxygenated hemoglobin (oxyHb) LFO amplitude bilateral at the frontal cortex at baseline and 15 minutes and 40 minutes after start of the GTN infusion.
RESULTS: GTN changed oxyHb LFO amplitude in FHM patients (P = .002), but not in healthy controls (P = .121). Only in FHM patients with coexisting common migraine types did GTN infusion induced changes in LFO amplitudes (P < .001), where post-hoc analysis revealed an increase in LFO amplitude 15 minutes (P = .003) and 40 (P = .013) minutes after start of infusion compared with baseline. Interestingly, GTN infusion induced no changes in LFO amplitude in patients with a pure FHM phenotype (P = .695).
CONCLUSION: FHM patients with a mixed phenotype (coexisting common type of migraine) showed an increase in oxyHb LFO amplitude during GTN infusion, whereas FHM patients with pure phenotype showed no changes. These data suggest possible differences in frontal cortical nitric oxide vascular sensitivity between FHM patients with a mixed phenotype and patients with pure FHM.
Henrik W Schytz; Jakob M Hansen; Dorte Phillip; Juliette Selb; David A Boas; Messoud Ashina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-21
Journal Detail:
Title:  Headache     Volume:  52     ISSN:  1526-4610     ISO Abbreviation:  Headache     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-07-04     Completed Date:  2012-11-27     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1146-54     Citation Subset:  IM    
Copyright Information:
© 2012 American Headache Society.
Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
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MeSH Terms
Blood Vessels / drug effects,  metabolism*
Case-Control Studies
Cerebral Cortex / blood supply*
Frontal Lobe / blood supply
Hemoglobins / metabolism
Middle Aged
Migraine with Aura / metabolism*
Nitric Oxide / metabolism*
Nitric Oxide Donors / pharmacology
Nitroglycerin / pharmacology
Spectroscopy, Near-Infrared*
Time Factors
Grant Support
Reg. No./Substance:
0/Hemoglobins; 0/Nitric Oxide Donors; 10102-43-9/Nitric Oxide; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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