| Nitric oxide metabolite production during exercise in chronic fatigue syndrome: a case-control study. | |
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MedLine Citation:
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PMID: 20469961 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Chronic fatigue syndrome (CFS) is a disabling illness of unknown etiology that is characterized by fatigue associated with a reduced ability to work, lasting for more than 6 months, and accompanied by a specific set of symptoms. The diagnosis remains difficult because of the absence of laboratory tests and is, therefore, made largely on the basis of the symptoms reported by the patient. The aim of this study was to analyze differences in blood nitrate levels in CFS patients and a matched control group after a physical exercise test. METHODS: Forty-four consecutive female patients with CFS and 25 healthy women performed an exercise test using a cycle ergometer with monitoring of cardiopulmonary response. Blood samples were obtained for biochemical analyses of glucose, lactate, and nitrates at the beginning (under resting conditions) and after the maximal and supramaximal tests. RESULTS: Plasma nitrates differed between the groups, with higher values in the CFS group (F = 6.93, p = 0.003). Nitrate concentration increased in relation to workload and reached higher values in the CFS group, the maximum difference with respect to the control group being 295% (t = 4.88, p < 0.001). CONCLUSIONS: The main result of the present study is that nitric oxide (NO) metabolites (nitrates) showed a much higher increase after a maximal physical test in CFS patients than in a group of matched subjects. This combination (exercise plus NO response evaluation) may be useful in the assessment of CFS. |
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Authors:
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Andrea Suárez; Elisabet Guillamó; Teresa Roig; Alicia Blázquez; José Alegre; Jordi Bermúdez; José Luis Ventura; Ana María García-Quintana; Agustí Comella; Ramon Segura; Casimiro Javierre |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of women's health (2002) Volume: 19 ISSN: 1931-843X ISO Abbreviation: J Womens Health (Larchmt) Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159262 Medline TA: J Womens Health (Larchmt) Country: United States |
Other Details:
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Languages: eng Pagination: 1073-7 Citation Subset: IM |
Affiliation:
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Department of Physiological Sciences II, Medical School, University of Barcelona, L'Hospitalet, Barcelona, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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