Document Detail


Nitric Oxide Donors for Cardiovascular Implant Applications.
MedLine Citation:
PMID:  23136136     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In an era of increased cardiovascular disease burden in the ageing population, there is great demand for devices that come in to contact with the blood such as heart valves, stents, and bypass grafts that offer life saving treatments. Nitric oxide (NO) elution from healthy endothelial tissue that lines the vessels maintains haemostasis throughout the vasculature. Surgical devices that release NO are desirable treatment options and N-diazeniumdiolates and S-nitrosothiols are recognized as preferred donor molecules. There is a keen interest to investigate newer methods by which NO donors can be retained within biomaterials so that their release and kinetic profiles can be optimized. A range of polymeric scaffolds incorporating microparticles and nanomaterials are presenting solutions to current challenges, and have been investigated in a range of clinical applications. This review outlines the application of NO donors for cardiovascular therapy using biomaterials that release NO locally to prevent thrombosis and intimal hyperplasia (IH) and enhance endothelialization in the fabrication of next generation cardiovascular device technology.
Authors:
Noora Naghavi; Achala de Mel; Omid Sadeghi Alavijeh; Brian G Cousins; Alexander M Seifalian
Related Documents :
24006146 - Impaired vascular endothelial growth factor a and inflammation in patients with periphe...
18567896 - Metformin improves endothelial function in normoinsulinemic pcos patients: a new prospe...
14644386 - Effects of 3-deazaadenosine on homocysteine and atherosclerosis in apolipoprotein e-def...
18463666 - Assessment of endothelial function in the patient with erectile dysfunction: an opportu...
8362636 - Toxic effects of ouabain on the rabbit corneal endothelium.
19141676 - Fasciclin 2, the drosophila orthologue of neural cell-adhesion molecule, inhibits egf r...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Small (Weinheim an der Bergstrasse, Germany)     Volume:  -     ISSN:  1613-6829     ISO Abbreviation:  Small     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235338     Medline TA:  Small     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
UCL Centre for Nanotechnology & Regenerative Medicine, University College London, UK, Tel: +44 20 7830 2901.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Maternal menopause as a predictor of anti-Mullerian hormone level and antral follicle count in daugh...
Next Document:  Multivariate data analysis for finding the relevant fatty acids contributing to the melting fraction...